Department of Methodology of the Investigation, National Institute of Endocrinology, Havana, MD. Apdo.6275, Habana 6, Cuba.
Int J Endocrinol. 2012;2012:382719. doi: 10.1155/2012/382719. Epub 2012 Jun 21.
For to determine the effect of Diamel on the insulin resistance, insulin sensitivity, and sexual hormones results in women with polycystic ovary syndrome (PCOS). A study was carried out on 37 patients with this disorder. A triple-blind clinical trial was designed in which the Diamel food supplement was compared with a placebo. The women with reproductive ages were randomly distributed in two groups, with 18 and 19 women respectively, and they took Diamel or placebo and were followed up during 6 months with clinical and biochemical evaluation. A significant decrease in the HOMA-IR from the initial value at six months was observed in the group with Diamel. The insulin sensitivity improved considerably in this group. The rate of menstrual recovery was higher in the group with Diamel, and two patients from this group obtained pregnancy. The hormone levels shows a significant decrease in testosterone at 3 months in the group with Diamel compared with the control group. The LH also decreases in the same group when comparing the start with 6 months.We concluded that the Diamel decreases insulin resistance and improves sensitivity to this hormone in women with PCOS, with improvement in the levels of LH and testosterone.
为了确定 Diamel 对多囊卵巢综合征（PCOS）妇女的胰岛素抵抗、胰岛素敏感性和性激素的影响，进行了一项针对 37 名该病患者的研究。设计了一项三盲临床试验，将 Diamel 食品补充剂与安慰剂进行比较。有生育能力的妇女被随机分为两组，每组 18 人和 19 人，分别服用 Diamel 或安慰剂，并在 6 个月的临床和生化评估中进行随访。在 Diamel 组，HOMA-IR 从 6 个月时的初始值显著下降。该组的胰岛素敏感性显著改善。Diamel 组的月经恢复率较高，且该组有两名患者怀孕。与对照组相比，Diamel 组的睾丸激素水平在 3 个月时显著下降，而在同一组中，LH 也随着 6 个月的开始而下降。我们得出结论，Diamel 可降低 PCOS 妇女的胰岛素抵抗，并提高对这种激素的敏感性，同时改善 LH 和睾丸激素水平。
