细胞间谷氨酸信号在神经系统内外的作用。
Intercellular glutamate signaling in the nervous system and beyond.
机构信息
Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607.
出版信息
ACS Chem Neurosci. 2010 Jan 20;1(1):4-12. doi: 10.1021/cn900006n. Epub 2009 Oct 9.
Abstract
Most intercellular glutamate signaling in the nervous system occurs at synapses. Some intercellular glutamate signaling occurs outside synapses, however, and even outside the nervous system where high ambient extracellular glutamate might be expected to preclude the effectiveness of glutamate as an intercellular signal. Here, I briefly review the types of intercellular glutamate signaling in the nervous system and beyond, with emphasis on the diversity of signaling mechanisms and fundamental unanswered questions.
摘要
大多数细胞间谷氨酸信号在神经系统中发生在突触处。然而，有些细胞间谷氨酸信号发生在突触之外，甚至发生在神经系统之外，在这些地方，高浓度的细胞外谷氨酸可能会排除谷氨酸作为细胞间信号的有效性。在这里，我简要回顾了神经系统内外的细胞间谷氨酸信号的类型，重点介绍了信号机制的多样性和尚未解决的基本问题。
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