Roesler Bruna Maria, Costa Sandra Cecília Botelho, Zeitune José Murilo Robilotta
Department of Clinical Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 13.081-970 Campinas, SP, Brazil.
ISRN Gastroenterol. 2012;2012:935410. doi: 10.5402/2012/935410. Epub 2012 Jun 13.
Helicobacter pylori is the most important carcinogen for gastric adenocarcinoma. Bacterial virulence factors are essential players in modulating the immune response involved in the initiation of carcinogenesis in the stomach; host genetic factors contribute to the regulation of the inflammatory response and to the aggravation of mucosal damage. In terms of environmental factors, salt intake and smoking contribute to the development of lesions. Various therapeutic schemes are proposed to eradicate H. pylori infection, which could potentially prevent gastric cancer, offering the greatest benefit if performed before premalignant changes of the gastric mucosa have occurred.
幽门螺杆菌是胃腺癌最重要的致癌物。细菌毒力因子是调节参与胃癌发生起始阶段免疫反应的关键因素；宿主遗传因素有助于调节炎症反应并加剧黏膜损伤。在环境因素方面，盐摄入和吸烟会促使病变发展。人们提出了各种治疗方案来根除幽门螺杆菌感染，这有可能预防胃癌，若在胃黏膜发生癌前病变之前进行根除治疗，则益处最大。
