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丁香油中β-石竹烯对清除的影响。

Effect of β-caryophyllene from Cloves Extract on Eradication in Mouse Model.

机构信息

Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.

SFC bio Co., Ltd., 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea.

出版信息

Nutrients. 2020 Apr 4;12(4):1000. doi: 10.3390/nu12041000.

DOI:10.3390/nu12041000
PMID:32260414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7230661/
Abstract

New antibacterial treatments against are needed as is acquiring antibiotic resistance. β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication of in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti- efficacy of β-caryophyllene, a total of 160 mice were divided into eight groups ( = 10 each) and were administered different treatments for 2 and 4 weeks. eradication was assessed using a Campylobacter-like organism (CLO) test and qPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively. levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in -infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment of infection.

摘要

需要新的抗菌疗法来对抗 ，因为 正在产生抗生素耐药性。β-石竹烯是一种天然的双环倍半萜烯，具有抗炎和抗菌作用。本研究调查了来自 β-石竹烯的 H-002119-00-001 对小鼠模型中 根除的影响及其对胃黏膜炎症的影响。为了评估 β-石竹烯的抗 疗效，将总共 160 只小鼠分为 8 组（每组 10 只），并接受不同的治疗 2 和 4 周。使用弯曲杆菌样生物体 (CLO) 试验和胃黏膜的 qPCR 评估 根除。使用组织学和免疫染色评估胃黏膜炎症水平。H-002119-00-001 体外降低细菌负荷。当 H-002119-00-001 每天一次给予小鼠 2 周时，CLO 试验显示第 6、7 和 8 组的治愈率分别为 40.0%、60.0%和 70.0%。H-002119-00-001 治疗后胃黏膜 水平呈剂量依赖性降低。H-002119-00-001 还降低了胃黏膜的炎症水平。H-002119-00-001 改善了 感染的小鼠模型中的炎症并降低了细菌负荷。H-002119-00-001 是治疗 感染的一种有前途且有效的治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/b617011311cc/nutrients-12-01000-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/3431fd928770/nutrients-12-01000-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/f0fb269ebbbb/nutrients-12-01000-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/d00589a42797/nutrients-12-01000-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/dd51fcf6f770/nutrients-12-01000-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/b617011311cc/nutrients-12-01000-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/3431fd928770/nutrients-12-01000-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/f0fb269ebbbb/nutrients-12-01000-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/d00589a42797/nutrients-12-01000-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/dd51fcf6f770/nutrients-12-01000-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a0/7230661/b617011311cc/nutrients-12-01000-g005.jpg

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