McCance D J, Mims C A
Infect Immun. 1979 Sep;25(3):998-1002. doi: 10.1128/iai.25.3.998-1002.1979.
Female mice infected at birth with 10(7) 50% tissue culture infective doses of polyoma virus were mated when at least 6 weeks old. Polyoma was not detected in any tissues of 27 female mice before mating except for trace amounts in the kidneys of 2 mice, but late in gestation polyoma virus could be found in the kidneys of 21 of 38 mice with titers of 10(3.7) to 10(6.2) 50% tissue culture infective doses per gram of kidney. The virus was not detected in the brain, salivary gland, lung, liver, spleen, ovaries, placenta, or fetuses during gestation. Nonpregnant females were injected with female sex hormones over a period of 17 days, and polyoma was then detected in kidneys of 4 of 18 mice. Treatment of cultures of mouse embryo fibroblasts with either sexhormones or a glucocorticosteroid resulted in approximately a threefold increase in the rate of infection of cells with polyoma virus.
出生时感染10⁷个50%组织培养感染剂量多瘤病毒的雌性小鼠，至少6周龄时进行交配。交配前，在27只雌性小鼠的任何组织中均未检测到多瘤病毒，只有2只小鼠的肾脏中有微量病毒，但在妊娠后期，38只小鼠中有21只的肾脏中可检测到多瘤病毒，每克肾脏的滴度为10³·⁷至10⁶·²个50%组织培养感染剂量。妊娠期间，在大脑、唾液腺、肺、肝脏、脾脏、卵巢、胎盘或胎儿中均未检测到该病毒。对未怀孕的雌性小鼠注射雌性激素17天，然后在18只小鼠中的4只小鼠的肾脏中检测到多瘤病毒。用性激素或糖皮质激素处理小鼠胚胎成纤维细胞培养物，导致细胞被多瘤病毒感染的速率增加约三倍。
