Rosenstreich D L, Glode L M
J Immunol. 1975 Sep;115(3):777-80.
Spleen cells from C3H/HeJ mice respond very poorly to the mitogenic action of endotoxin (LPS) in vitro whereas cells from a very closely related strain, C3H/HeN respond very well. An analysis of the genetic similarity of these two strains was performed. There is no significant MLR measurable between cells of these strains under a variety of culture conditions. They do not manifest a significant graft-vs-host response nor do they reject reciprocal skin grafts. Because of this genetic similarity, it is possible to reconstitute the LPS response of nonresponder mice by an adoptive transfer of spleen cells from C3H/HeN mice. This strain pair should therefore prove useful in analyzing the genetic and cellular basis of endotoxin reactivity.
C3H/HeJ小鼠的脾细胞在体外对内毒素（LPS）的促有丝分裂作用反应很差，而来自密切相关品系C3H/HeN的细胞反应则很好。对这两个品系的遗传相似性进行了分析。在各种培养条件下，这些品系的细胞之间没有可测量的显著混合淋巴细胞反应。它们没有表现出显著的移植物抗宿主反应，也不会排斥相互的皮肤移植。由于这种遗传相似性，通过从C3H/HeN小鼠过继转移脾细胞，可以重建无反应小鼠的LPS反应。因此，这一品系对在分析内毒素反应性的遗传和细胞基础方面应会证明是有用的。
