Banu Jameela, Varela Erika, Bahadur Ali N, Soomro Raheela, Kazi Nishu, Fernandes Gabriel
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA.
J Osteoporos. 2012;2012:101206. doi: 10.1155/2012/101206. Epub 2012 Jun 21.
Women drastically loose bone during and after menopause leading to osteoporosis, a disease characterized by low bone mass increasing the risk of fractures with minor trauma. Existing therapies mainly reduce bone resorption, however, all existing drugs have severe side effects. Recently, the focus is to identify alternative medicines that can prevent and treat osteoporosis with minimal or no side effects. We used Cissus quadrangularis (CQ), a medicinal herb, to determine its effects on bone loss after ovariectomy in C57BL/6 mice. Two-month old mice were either sham operated or ovariectomized and fed CQ diet. After eleven weeks, mice were sacrificed and the long bones scanned using pQCT and μCT. In the distal femoral metaphysis, femoral diaphysis, and proximal tibia, control mice had decreased cancellous and cortical bone, while CQ-fed mice showed no significant differences in the trabecular number, thickness, and connectivity density, between Sham and OVX mice, except for cortical bone mineral content in the proximal tibia. There were no changes in the bone at the tibio-fibular junction between groups. We conclude that CQ effectively inhibited bone loss in the cancellous and cortical bones of femur and proximal tibia in these mice.
女性在绝经期间及绝经后会急剧骨质流失，导致骨质疏松症，这是一种以骨量低为特征的疾病，会增加轻微创伤导致骨折的风险。现有疗法主要是减少骨吸收，然而，所有现有药物都有严重的副作用。最近，重点是寻找能够预防和治疗骨质疏松症且副作用最小或无副作用的替代药物。我们使用了药用植物四角金（CQ），来确定其对C57BL/6小鼠卵巢切除术后骨质流失的影响。将两个月大的小鼠进行假手术或卵巢切除，并喂食CQ饮食。十一周后，处死小鼠，使用外周定量计算机断层扫描（pQCT）和微计算机断层扫描（μCT）对长骨进行扫描。在股骨远端干骺端、股骨干和胫骨近端，对照小鼠的松质骨和皮质骨减少，而喂食CQ的小鼠在假手术组和卵巢切除组之间，除了胫骨近端的皮质骨矿物质含量外，小梁数量、厚度和连接密度没有显著差异。两组之间胫腓关节处的骨骼没有变化。我们得出结论，CQ有效抑制了这些小鼠股骨和胫骨近端松质骨和皮质骨的骨质流失。
