成纤维细胞干扰素与免疫干扰素混合制剂对干扰素活性的增强作用。
Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon.
作者信息
Fleischmann W R, Georgiades J A, Osborne L C, Johnson H M
出版信息
Infect Immun. 1979 Oct;26(1):248-53. doi: 10.1128/iai.26.1.248-253.1979.
Abstract
Mixed preparations of fibroblast and immune interferons interacted with cells synergistically to cause the development of a much greater level of protection than expected on the basis of their separate activities. This increased level of protection was 5- to 20-fold greater than expected on the basis of a simple additive effect of the interferons. The potentiating factor copurified with both fibroblast interferon and immune interferon as they were partially purified. The potentiation was not an artifact of a more rapid development of immune interferon-induced antiviral resistance in the presence of fibroblast interferon. The results were consistent with the hypothesis that fibroblast and immune interferons mutually potentiate each other, thus supporting the supposition that they have different modes of action.
摘要
成纤维细胞干扰素和免疫干扰素的混合制剂与细胞协同相互作用，产生的保护水平比根据它们各自的活性预期的要高得多。这种增强的保护水平比基于干扰素简单相加效应预期的高5至20倍。在对成纤维细胞干扰素和免疫干扰素进行部分纯化时，增效因子与它们一起被共纯化。这种增效作用不是在存在成纤维细胞干扰素的情况下免疫干扰素诱导的抗病毒抗性更快发展的假象。这些结果与成纤维细胞干扰素和免疫干扰素相互增强的假设一致，从而支持了它们具有不同作用方式的推测。
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