在小鼠淋巴因子制剂中诱导干扰素作用抑制剂

Induction of an inhibitor of interferon action in a mouse lymphokine preparation.

作者信息

Fleischmann W R, Georgiades J A, Osborne L C, Dianzani F, Johnson H M

出版信息

Infect Immun. 1979 Dec;26(3):949-55. doi: 10.1128/iai.26.3.949-955.1979.

DOI:10.1128/iai.26.3.949-955.1979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414711/

Abstract

An inhibitor of interferon action was identified in mouse lymphokine preparations. The inhibito was first detected in the supernatant fluid of mouse spleen cells at 72 h after stimulation by staphylococcal enterotoxin A. Inhibitor was not detected in supernatant fluids from unstimulated cultures. This inhibitor blocks the antiviral activity of both immune and fibroblast interferons. The inhibitor was purified 1,000-fold by two-step column chromatography. The partially purified inhibitor blocked the antiviral activity of up to 400 U of interferon. The immunosuppressive effect of interferon was also blocked by the inhibitor, suggesting that the inhibitor may modulate the immunoregulatory function of interferon.

摘要

在小鼠淋巴因子制剂中鉴定出一种干扰素作用抑制剂。该抑制剂最初是在经金黄色葡萄球菌肠毒素A刺激72小时后的小鼠脾细胞上清液中检测到的。未刺激培养物的上清液中未检测到抑制剂。这种抑制剂可阻断免疫干扰素和成纤维细胞干扰素的抗病毒活性。通过两步柱色谱法将该抑制剂纯化了1000倍。部分纯化的抑制剂可阻断高达400 U干扰素的抗病毒活性。该抑制剂还可阻断干扰素的免疫抑制作用，这表明该抑制剂可能调节干扰素的免疫调节功能。

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本文引用的文献

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Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。

J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.

2

[Factors antagonizing the antiviral action of interferon extracts of different human sarcomas].[不同人类肉瘤干扰素提取物抗病毒作用的拮抗因素]

C R Acad Hebd Seances Acad Sci D. 1969 Dec 22;269(25):2628-30.

3

[Stimulons, interferon-antagonistic factors favoring the intracellular multiplication of viruses].[刺激子，有利于病毒在细胞内增殖的干扰素拮抗因子]

C R Acad Hebd Seances Acad Sci D. 1965 Nov 15;261(20):4282-5.

4

Effects of interferon on antibody synthesis in vitro.干扰素对体外抗体合成的影响。

J Immunol. 1974 Aug;113(2):438-44.

5

On the mechanism of the ability of certain viruses to block the action of interferon.关于某些病毒阻断干扰素作用能力的机制

Acta Virol. 1966 May;10(3):268-70.

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Effect of interferon on virus production from isolated single cells.干扰素对从分离的单个细胞产生病毒的影响。

J Gen Virol. 1973 Aug;20(2):127-37. doi: 10.1099/0022-1317-20-2-127.

7

High interferon producing line of transformed murine cells.转化鼠细胞的高干扰素产生系。

J Gen Virol. 1972 Oct;17(1):107-9. doi: 10.1099/0022-1317-17-1-107.

8

Repression of interferon action: induced dedifferentiation of embryonic cells.干扰素作用的抑制：诱导胚胎细胞去分化。

Science. 1971 Jan 8;171(3966):77-9. doi: 10.1126/science.171.3966.77.

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