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α或β干扰素与重组γ干扰素混合物对淋巴细胞自然杀伤作用的增强

Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon.

作者信息

Weigent D A, Langford M P, Fleischmann W R, Stanton G J

出版信息

Infect Immun. 1983 Apr;40(1):35-8. doi: 10.1128/iai.40.1.35-38.1983.

DOI:10.1128/iai.40.1.35-38.1983
PMID:6403469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC264814/
Abstract

Human lymphocytes were treated with human alpha (IFN-alpha), beta (IFN-beta), or recombinant gamma (IFN-gamma) interferons separately or in combination to determine their ability to enhance natural killing against mouse L cell targets. Our results showed that recombinant IFN-gamma was approximately 50 times more active per unit of antiviral activity than either IFN-alpha or IFN-beta. Moreover, the levels of natural killing by lymphocytes treated with combinations of IFN-alpha and IFN-beta were additive, whereas combinations of recombinant IFN-gamma and IFN-alpha or recombinant IFN-gamma and IFN-beta were synergistic. The development of natural killing in lymphocytes treated with recombinant IFN-gamma did not occur more rapidly but reached higher levels (62%) than that observed with lymphocytes treated with IFN-alpha or IFN-beta (15%). The results suggest the importance of IFN-gamma and mixtures of IFN-gamma with IFN-alpha or IFN-beta in the enhancement of natural killing activity against virus infections and neoplasia.

摘要

将人淋巴细胞分别或联合用人α干扰素（IFN-α）、β干扰素（IFN-β）或重组γ干扰素（IFN-γ）进行处理，以确定它们增强对小鼠L细胞靶标的自然杀伤能力。我们的结果显示，每单位抗病毒活性，重组IFN-γ的活性比IFN-α或IFN-β高约50倍。此外，用IFN-α和IFN-β联合处理的淋巴细胞的自然杀伤水平是相加的，而重组IFN-γ与IFN-α或重组IFN-γ与IFN-β的联合处理则具有协同作用。用重组IFN-γ处理的淋巴细胞中自然杀伤的发展速度并不更快，但比用IFN-α或IFN-β处理的淋巴细胞（15%）达到更高水平（62%）。结果表明IFN-γ以及IFN-γ与IFN-α或IFN-β的混合物在增强针对病毒感染和肿瘤的自然杀伤活性方面的重要性。

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本文引用的文献

1
Neutralization of native human gamma interferon (HuIFN gamma) by antibodies to a synthetic peptide encoded by the 5' end of HuIFN gamma cDNA.用人γ干扰素（HuIFNγ）cDNA 5'端编码的合成肽抗体对天然人γ干扰素（HuIFNγ）进行中和。
J Immunol. 1982 Dec;129(6):2357-9.
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Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.人免疫干扰素cDNA的分子克隆及其在真核细胞中的表达。
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Potentiation of the direct anticellular activity of mouse interferons: mutual synergism and interferon concentration dependence.小鼠干扰素直接抗细胞活性的增强：相互协同作用及干扰素浓度依赖性
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The activity of interferon on ultraviolet light-induced squamous cell carcinomas in mice.干扰素对紫外线诱导的小鼠鳞状细胞癌的作用。
J Am Acad Dermatol. 1981 Jul;5(1):61-3. doi: 10.1016/s0190-9622(81)70078-1.
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Interferon modulation of natural killer cell activity.干扰素对自然杀伤细胞活性的调节作用。
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Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity.小鼠自然杀伤细胞培养：白细胞介素-2和干扰素对细胞生长及细胞毒性反应性的影响
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