Kim M W, Hong S-C, Choi J S, Han J-Y, Oh M-J, Kim H J, Nava-Ocampo A, Koren G
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea.
J Obstet Gynaecol. 2012 Aug;32(6):520-4. doi: 10.3109/01443615.2012.693984.
The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.6-73) vs 25 (7.3-105.5) p < 0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.7-28.2) vs 5.9 (1.8-14.6) μmol/ml, p < 0.05; and 5.8 (2.6-14.4) vs 4.2 (0.7-7.9) ng/ml, p < 0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.
本研究的目的是评估母血和/或脐血叶酸/同型半胱氨酸浓度与不良妊娠结局之间的关系。研究人群包括单胎孕妇的随机样本，我们在分娩时测量了母血或脐血中的总同型半胱氨酸和叶酸。总共招募了227名孕妇。早产组母血中叶酸浓度往往显著低于足月分娩组（中位数（95%可信区间），14.4（3.6 - 73）对25（7.3 - 105.5），p < 0.01）。子痫前期组母血和脐血中的总同型半胱氨酸显著高于血压正常组（分别为7.9（1.7 - 28.2）对5.9（1.8 - 14.6）μmol/ml，p < 0.05；以及5.8（2.6 - 14.4）对4.2（0.7 - 7.9）ng/ml，p < 0.05）。较低的母血血清叶酸浓度与早产相关，而较高的母血血浆同型半胱氨酸浓度与子痫前期相关。
