Department of Microbiology, MIMSR Medical College, Latur, Maharashtra, India Department of Surgery, MIMSR Medical College, Latur, Maharashtra, India Department of Microbiology, Medical Microbiology Research Laboratory, Nagpur University, Nagpur, Maharashtra, India Department of Orthopaedics, MIMSR Medical College, Latur, Maharashtra, India Department of Physiotherapy, MIMSR Medical College, Latur, Maharashtra, India.
Int Wound J. 2013 Oct;10(5):585-9. doi: 10.1111/j.1742-481X.2012.01026.x. Epub 2012 Jul 11.
Infection is one of the most important obstacles in the wound-healing process. Conventional methods used for the treatment of wound infections have their own limitations and hence, are difficult to control. If infection is not addressed well in time, it will further increase morbidity and cost of treatment. An attempt was made to develop a simple and effective treatment modality by using citric acid as the sole antimicrobial agent to control bacterial infections of traumatic wounds. A total of 259 cases of traumatic wounds infected with a variety of bacteria were investigated for culture and susceptibility, and susceptibility to citric acid. Citric acid ointment (3%) was applied to traumatic wounds to determine its efficacy in their treatment of traumatic wounds. In a culture and susceptibility study, a total of 369 aerobic bacteria and 7 fungi were isolated, with Staphylococcus aureus (30.31%) being the most common isolate and ciprofloxacin (61.43%) being the most effective agent. All the isolates were found to be inhibited by citric acid in in vitro studies (minimum inhibitory concentration--500-2500 µg/ml). Citric acid ointment was found effective in controlling infections. Out of 259 cases, 244 (around 95%) were healed completely in 5-25 applications of 3% citric acid. As citric acid has antibacterial activity and wound-healing property; hence it is the best alternative for the treatment of traumatic wounds. Besides these properties, citric acid has no adverse effects and it is a good dressing agent.
感染是伤口愈合过程中最重要的障碍之一。传统的用于治疗伤口感染的方法都有其局限性，因此难以控制。如果感染不能及时得到有效处理，将会进一步增加发病率和治疗成本。本研究试图开发一种简单有效的治疗方法，使用柠檬酸作为唯一的抗菌剂来控制创伤性伤口的细菌感染。对 259 例感染了各种细菌的创伤性伤口进行了培养和药敏试验以及对柠檬酸的药敏试验。将柠檬酸软膏（3%）应用于创伤性伤口，以确定其治疗创伤性伤口的疗效。在培养和药敏研究中，共分离出 369 株需氧菌和 7 株真菌，其中金黄色葡萄球菌（30.31%）是最常见的分离株，环丙沙星（61.43%）是最有效的药物。所有分离株在体外研究中均被柠檬酸抑制（最小抑菌浓度 500-2500μg/ml）。柠檬酸软膏在控制感染方面非常有效。在 259 例患者中，244 例（约 95%）在 5-25 次使用 3%柠檬酸后的 5-25 次应用中完全治愈。由于柠檬酸具有抗菌活性和促进伤口愈合的特性；因此，它是治疗创伤性伤口的最佳选择。除了这些特性外，柠檬酸没有不良反应，是一种很好的敷药剂。
