Afzal Rumila, Kaleem Sidra, Khan Aslam, Anwar Fareeha, Ilyas Umair, Alhegaili Alaa S, Ali Mansoor, Ali Sajid
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Pakistan.
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Inflammopharmacology. 2025 Jul 23. doi: 10.1007/s10787-025-01857-0.
Veratric acid, a naturally occurring derivative of benzoic acid present in various plants and fruits, has been reported to possess antioxidant, anti-inflammatory, antimicrobial, and antihypertensive properties. This study was designed to evaluate the effects of veratric acid (VA) and zinc (ZN) on wound healing in rats, assessing their individual (per se) and combined effects to determine the potential for synergistic healing benefits. In an experimental rat model, key variables, including wound closure rate, collagen synthesis, angiogenesis, and inflammation, were assessed in the presence or absence of VA and ZN, both individually and in combination. According to the study's findings, the combination of VA and ZN (10% + 10%) significantly enhances wound healing by promoting collagen synthesis, accelerating angiogenesis (the formation of new blood vessels), and reducing inflammation, thereby facilitating wound closure. The combination of veratric acid and zinc further amplified these effects, indicating a potential synergistic interaction between the two compounds. In the treatment groups, hydroxyproline levels and antioxidant parameters-including catalase, superoxide dismutase, nitric oxide, malondialdehyde, and glutathione-were significantly restored compared to the diseased control group, showing a recovery pattern similar to that of the standard control group. This study aims to provide the therapeutic potential of veratric acid, zinc, and combinations of both. The combination group shows more promising results as compared to their individual effects, indicating synergistic effects. Our data demonstrated a positive effect of the combination group along with the underlying mechanisms, suggesting its clinical potential for wound-healing applications.
藜芦酸是一种天然存在的苯甲酸衍生物，存在于各种植物和水果中，据报道具有抗氧化、抗炎、抗菌和抗高血压特性。本研究旨在评估藜芦酸（VA）和锌（ZN）对大鼠伤口愈合的影响，评估它们各自的（本身的）和联合的效果，以确定协同促进愈合的潜力。在一个实验性大鼠模型中，在有或没有VA和ZN的情况下，分别单独和联合评估关键变量，包括伤口闭合率、胶原蛋白合成、血管生成和炎症。根据该研究的结果，VA和ZN（10% + 10%）的组合通过促进胶原蛋白合成、加速血管生成（新血管的形成）和减轻炎症，从而显著促进伤口愈合，进而促进伤口闭合。藜芦酸和锌的组合进一步放大了这些效果，表明这两种化合物之间存在潜在的协同相互作用。在治疗组中，与患病对照组相比，羟脯氨酸水平和抗氧化参数（包括过氧化氢酶、超氧化物歧化酶、一氧化氮、丙二醛和谷胱甘肽）显著恢复，显示出与标准对照组相似的恢复模式。本研究旨在提供藜芦酸、锌及其两者组合的治疗潜力。与它们各自的效果相比，组合组显示出更有前景的结果，表明有协同作用。我们的数据证明了组合组的积极效果以及潜在机制，表明其在伤口愈合应用中的临床潜力。
