Riis B, Rattan S I, Clark B F, Merrick W C
Department of Chemistry, Aarhus University, Denmark.
Trends Biochem Sci. 1990 Nov;15(11):420-4. doi: 10.1016/0968-0004(90)90279-k.
In eukaryotes, peptide chain elongation is mediated by elongation factors EF-1 and EF-2. EF-1 is composed of a nucleotide-binding protein EF-1 alpha, and a nucleotide exchange protein complex, EF-1 beta gamma, while EF-2 catalyses the translocation of peptidyl-tRNA on the ribosome. Elongation factors are highly conserved among different species and may be involved in functions other than protein synthesis, such as organization of the mitotic apparatus, signal transduction, developmental regulation, ageing and transformation. Yeast contains a third factor, EF-3, whose structure and function is not yet well understood.
在真核生物中，肽链延伸由延伸因子EF-1和EF-2介导。EF-1由一个核苷酸结合蛋白EF-1α和一个核苷酸交换蛋白复合物EF-1βγ组成，而EF-2催化肽基-tRNA在核糖体上的易位。延伸因子在不同物种间高度保守，可能参与蛋白质合成以外的其他功能，如有丝分裂装置的组织、信号转导、发育调控、衰老和转化。酵母含有第三种因子EF-3，其结构和功能尚未完全明确。
