相关起源的二倍体和四倍体淋巴瘤细胞中爱泼斯坦-巴尔病毒基因组数量、核抗原量与早期抗原诱导性之间的关系。
Relationship between Epstein-Barr virus genome number, amount of nuclear antigen, and early antigen inducibility in diploid and tetraploid lymphoma cells of related origin.
作者信息
Shapiro I M, Luka J, Andersson-Anvret M, Klein G
出版信息
Intervirology. 1979;12(1):19-25. doi: 10.1159/000149064.
PMID:227812
Abstract
In a collection of near-diploid and near-tetraploid Raji sublines and somatic Raji/Raji hybrids a linear relationship was found between the number of Epstein-Barr virus (EBV) genome copies and the relative amount of EBV-determined nuclear antigen per cell. Inducibility of the viral cycle by iododeoxyuridine and by P3HR-1 virus superinfection coulb be related to the number of resident EBV genome copies per haploid target cell. The implications of these findings are discussed.
摘要
在一组近二倍体和近四倍体的拉吉细胞亚系以及体细胞拉吉/拉吉杂种中，发现爱泼斯坦 - 巴尔病毒（EBV）基因组拷贝数与每个细胞中EBV决定的核抗原相对量之间存在线性关系。碘脱氧尿苷和P3HR - 1病毒超感染对病毒周期的诱导能力可能与每个单倍体靶细胞中常驻EBV基因组拷贝数有关。讨论了这些发现的意义。
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