宿主细胞对爱泼斯坦-巴尔病毒诱导的调控。
Host cell regulation of induction of Epstein-Barr virus.
作者信息
Glaser R, Nonoyama M
出版信息
J Virol. 1974 Jul;14(1):174-6. doi: 10.1128/JVI.14.1.174-176.1974.
Abstract
When Epstein-Barr virus (EBV) negative cells (Raji) were treated with iododeoxyuridine, only the early antigen (EA) component was induced. There was no significant increase in EBV DNA and no virus particles were observed. Somatic-cell hybrids were prepared from the fusion of Raji and D98 cells (D98/Raji). When these cells were treated with iododeoxyuridine, early antigen EBV DNA, and virus particles were synthesized. These data suggest cellular control over the expression of the EBV genome.
摘要
当用碘脱氧尿苷处理爱泼斯坦-巴尔病毒（EBV）阴性细胞（拉吉细胞）时，仅诱导出早期抗原（EA）成分。EBV DNA没有显著增加，也未观察到病毒颗粒。通过拉吉细胞和D98细胞（D98/Raji）融合制备了体细胞杂种。当用碘脱氧尿苷处理这些细胞时，会合成早期抗原EBV DNA和病毒颗粒。这些数据表明细胞对EBV基因组的表达具有控制作用。
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