Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Head Neck. 2012 Feb;34(2):213-8. doi: 10.1002/hed.21714. Epub 2011 Apr 11.
Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeal carcinomas.
We performed p16 immunohistochemistry and in situ hybridization for Epstein-Barr virus (EBV) and HPV on 45 carcinomas of the nasopharynx.
Thirty-four (76%) carcinomas were EBV-positive/HPV-negative, 7 (16%) were EBV-negative/HPV-negative, and 4 (9%) were EBV-negative/HPV-positive. HPV was more likely to be detected in carcinomas from white patients than non-white patients (16% vs 0%; p = .03). Of the 3 patients with HPV-positive carcinomas and available staging information, all were found to have extension into the oropharynx. All HPV-positive carcinomas were p16 positive, but none of the HPV-negative carcinomas were p16 positive (p < .001).
HPV can be detected in a subset of carcinomas involving the nasopharynx, but many of these may represent extension from an oropharyngeal primary. P16 immunohistochemistry is a reliable marker for separating EBV-related and HPV-related carcinomas of Waldheyer's ring.
人乳头瘤病毒（HPV）是口咽癌的病因之一，也被认为是鼻咽癌的病因之一。
我们对 45 例鼻咽癌进行了 p16 免疫组化和 Epstein-Barr 病毒（EBV）原位杂交检测。
34 例（76%）为 EBV 阳性/HPV 阴性，7 例（16%）为 EBV 阴性/HPV 阴性，4 例（9%）为 EBV 阴性/HPV 阳性。HPV 在白人患者中的检出率高于非白人患者（16%比 0%；p =.03）。在 3 例 HPV 阳性的鼻咽癌患者中，所有患者均有口咽侵犯。所有 HPV 阳性的鼻咽癌均为 p16 阳性，但所有 HPV 阴性的鼻咽癌均为 p16 阴性（p <.001）。
HPV 可在一部分涉及鼻咽的癌中检出，但其中许多可能代表来自口咽原发灶的扩展。p16 免疫组化是区分 EBV 相关和 HPV 相关的 Waldeyer 环鼻咽癌的可靠标志物。
