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小鼠肝小叶内脂滴分布的产后变化。

Postnatal changes in the distribution of lipid droplets within the liver lobule of the mouse.

作者信息

Asada M, Kanamura S

出版信息

J Anat. 1979 Sep;129(Pt 2):423-6.

PMID:227825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1233058/
Abstract

The changes in the distribution of lipid droplets in the liver lobule were studied during the postnatal development of the mouse. At birth, and 1 day after birth, lipid droplets were evenly distributed throughout the lobule. A slightly uneven distribution of the droplets, more in centrilobular areas, appeared 2 days after birth. After this the difference in the number of droplets between the cells of the centrilobular and periportal areas became progressively more marked reaching a maximum by 17 days of age, and then decreasing to the adult level between 21 and 24 days. Thus, heterogeneity among hepatocytes with respect to lipid content is not present in newborn mice but develops gradually during the postnatal development.

摘要

在小鼠出生后的发育过程中，对肝小叶中脂滴分布的变化进行了研究。出生时及出生后1天，脂滴均匀分布于整个小叶。出生后2天，脂滴分布略有不均，在小叶中心区域较多。此后，小叶中心区域和门静脉周围区域细胞之间的脂滴数量差异逐渐变得更加明显，在17日龄时达到最大值，然后在21至24日龄之间降至成年水平。因此，新生小鼠肝细胞在脂质含量方面不存在异质性，而是在出生后的发育过程中逐渐形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/1340f536cc2b/janat00238-0197-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/be135ea3a899/janat00238-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/2144e971eea0/janat00238-0197-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/9a08051134c9/janat00238-0197-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/67e339ff17cf/janat00238-0197-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/92b66c1cca53/janat00238-0197-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/9db0b1817dc7/janat00238-0197-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/1340f536cc2b/janat00238-0197-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/be135ea3a899/janat00238-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/2144e971eea0/janat00238-0197-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/9a08051134c9/janat00238-0197-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/67e339ff17cf/janat00238-0197-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/92b66c1cca53/janat00238-0197-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/9db0b1817dc7/janat00238-0197-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8308/1233058/1340f536cc2b/janat00238-0197-g.jpg

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本文引用的文献

1
Changes in the distribution of thymidine-3H labeled cells in the growing liver acinus of neonatal rats.
Dev Biol. 1970 Dec;23(4):524-33. doi: 10.1016/0012-1606(70)90138-7.
2
The postnatal development of the liver in a marsupial, Didelphis virginiana. 1. Light microscopy.有袋动物弗吉尼亚负鼠肝脏的产后发育。1. 光学显微镜检查。
J Anat. 1973 Sep;115(Pt 3):327-46.
3
The postnatal development of the rabbit liver.兔子肝脏的出生后发育。
Biol Neonate. 1972;20(5):404-13. doi: 10.1159/000240482.
4
Growth, mitosis and morphogenesis of the simple liver acinus in neonatal rats.新生大鼠单纯肝腺泡的生长、有丝分裂和形态发生
Dev Biol. 1974 Nov;41(1):22-30. doi: 10.1016/0012-1606(74)90279-6.
5
Postanal changes in the localization of glucose 6-phosphatase activity within the liver lobule of the mouse.小鼠肝小叶内葡萄糖-6-磷酸酶活性定位的肛门后变化。
Anat Rec. 1975 Mar;181(3):635-40. doi: 10.1002/ar.1091810306.