College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, PR China.
Chem Biodivers. 2012 Jul;9(7):1382-8. doi: 10.1002/cbdv.201100238.
Three new iridoids, jatairidoids A-C (1-3, resp.), have been isolated from the roots of Valeriana jatamansi (V. wallichii). Their structures were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR). Compounds 1 and 2 are C(3)-epimers. The three compounds were evaluated for their neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. All the isolates exhibited moderate neuroprotective effects.
从缬草（缬草属植物）的根中分离得到三种新的裂环环烯醚萜类化合物，分别为 jatairidoids A-C（1-3）。通过光谱方法（IR、ESI-MS、HR-ESI-MS、1D 和 2D-NMR）阐明了它们的结构。化合物 1 和 2 是 C(3)-差向异构体。评估了这三种化合物对 MPP(+)-诱导的人多巴胺能神经母细胞瘤 SH-SY5Y 细胞神经元细胞死亡的神经保护作用。所有分离物均表现出中等的神经保护作用。
