College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, 94 Weijin Road, Tianjin, P.R. China.
Nat Prod Res. 2012 Nov;26(21):1996-2001. doi: 10.1080/14786419.2011.636747. Epub 2011 Nov 25.
A new iridoid, jatamandoid A (1), and four known analogues (2-5) were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). Five compounds were evaluated and compounds 1, 2 and 5 showed moderate neuroprotective effects against MPP(+)-induced neuronal SH-SY5Y cell death.
从缬草（Valeriana jatamansi）根部分离得到一个新的裂环烯醚萜类化合物 jatamandoid A（1）和四个已知类似物（2-5）。根据广泛的光谱分析（IR、ESI-MS、HR-ESI-MS、1-D 和 2-D NMR）确定了它们的结构。对五种化合物进行了评估，化合物 1、2 和 5 对 MPP(+)-诱导的神经元 SH-SY5Y 细胞死亡表现出中等的神经保护作用。
