在儿童克罗恩病中，淀粉酶水平极高可能是良性的。
A very high amylase can be benign in paediatric Crohn's disease.
作者信息
Venkataraman Devasmitha, Howarth Lucy, Beattie Robert Mark, Afzal Nadeem Ahmad
机构信息
Paediatrics Department, University Hospital Southampton, Southampton, Hampshire, UK.
出版信息
BMJ Case Rep. 2012 Jul 10;2012:bcr0220125917. doi: 10.1136/bcr.02.2012.5917.
A 12.5-year-old boy with Crohn's disease with abdominal pain had a raised amylase of 1835 IU/l with normal lipase levels. Ultrasound showed no evidence of inflammation of pancreas. The amylase to creatinine clearance ratio, was 0.8% (reference interval 2%-5%; >6% consistent with acute pancreatitis; <1.6% with macroamylasemia), suggesting he had raised serum amylase with a corresponding reduced clearance of amylase in his urine, positively supporting the diagnosis of macroamylasemia. Macroamylasemia has no clinical significance other than misdiagnosis as acute pancreatitis. Awareness of this condition is important and a positive diagnosis should always be made to avoid unnecessary changes in treatments.
一名12.5岁患有克罗恩病且腹痛的男孩，淀粉酶水平升高至1835 IU/l，脂肪酶水平正常。超声检查未发现胰腺有炎症迹象。淀粉酶与肌酐清除率为0.8%（参考区间为2%-5%；>6%提示急性胰腺炎；<1.6%提示巨淀粉酶血症），表明他血清淀粉酶升高，同时尿中淀粉酶清除率相应降低，有力支持了巨淀粉酶血症的诊断。除了被误诊为急性胰腺炎外，巨淀粉酶血症并无临床意义。认识到这种情况很重要，应始终做出明确诊断，以避免不必要的治疗调整。
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