Yau G, Gregory M A, Gin T, Oh T E
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Anaesthesia. 1990 Dec;45(12):1020-3. doi: 10.1111/j.1365-2044.1990.tb14878.x.
We performed a double-blind comparison of six solutions for epidural analgesia in 90 healthy Chinese women with uncomplicated pregnancies. Patients were randomly allocated to receive 10 ml bupivacaine 0.125% or 0.25% plain, bupivacaine 0.125% with adrenaline 1.25 micrograms/ml, bupivacaine 0.25% with adrenaline 2.5 micrograms/ml or the latter two solutions with added fentanyl 50 micrograms. Analgesia was unsatisfactory in 30% of the bupivacaine 0.125% groups without fentanyl. The addition of adrenaline, compared with bupivacaine 0.25% plain, gave faster onset and longer duration of analgesia (p less than 0.05) which was similar to that found in both fentanyl groups. There were no differences in method of delivery or neonatal Apgar scores among groups. The least concentrated mixture that gave the best analgesia was the combination of bupivacaine 0.125% with adrenaline 1.25 micrograms/ml and fentanyl 50 micrograms.
我们对90名妊娠情况正常的健康中国女性进行了六种硬膜外镇痛溶液的双盲比较。患者被随机分配接受10毫升0.125%或0.25%的布比卡因原液、含1.25微克/毫升肾上腺素的0.125%布比卡因、含2.5微克/毫升肾上腺素的0.25%布比卡因，或后两种溶液加50微克芬太尼。在不含芬太尼的0.125%布比卡因组中，30%的患者镇痛效果不满意。与0.25%布比卡因原液相比，添加肾上腺素可使镇痛起效更快、持续时间更长（p<0.05），这与两个芬太尼组的情况相似。各组之间在分娩方式或新生儿阿普加评分方面没有差异。镇痛效果最佳的浓度最低的混合液是含1.25微克/毫升肾上腺素和50微克芬太尼的0.125%布比卡因。
