Diantini Ajeng, Subarnas Anas, Lestari Keri, Halimah Eli, Susilawati Yasmiwar, Julaeha Euis, Achmad Tri H, Suradji Eka W, Yamazaki Chiho, Kobayashi Kenji, Koyama Hiroshi, Abdulah Rizky
Division of Pharmacology and Clinical Pharmacy, University of Padjadjaran, Jatinangor 45363, Indonesia.
Oncol Lett. 2012 May;3(5):1069-1072. doi: 10.3892/ol.2012.596. Epub 2012 Feb 9.
Plants consumed by non-human primates represent potential drug sources for human disease management. In this study, we isolated kaempferol-3-O-rhamnoside as an active compound from the leaves of Schima wallichii Korth., a plant commonly consumed by non-human primates. Its anti-cancer activities, including its ability to induce apoptotic mechanisms, were investigated in MCF-7 breast cancer cells. Results showed that in MCF-7 cells, kaempferol-3-O-rhamnoside inhibits cell proliferation in a dose-dependent manner and promotes apoptosis via the activation of the caspase signaling cascade, which includes caspase-9, caspase-3 and PARP. Our results provide a basis for further exploration of kaempferol-3-O-rhamnoside as an active compound for potential anti-cancer therapeutics.
非人灵长类动物食用的植物是人类疾病治疗的潜在药物来源。在本研究中，我们从厚皮香（Schima wallichii Korth.）的叶子中分离出了活性化合物山奈酚-3-O-鼠李糖苷，厚皮香是一种非人灵长类动物常食用的植物。我们在MCF-7乳腺癌细胞中研究了其抗癌活性，包括诱导凋亡机制的能力。结果表明，在MCF-7细胞中，山奈酚-3-O-鼠李糖苷以剂量依赖的方式抑制细胞增殖，并通过激活包括caspase-9、caspase-3和PARP在内的caspase信号级联反应促进细胞凋亡。我们的研究结果为进一步探索山奈酚-3-O-鼠李糖苷作为潜在抗癌治疗的活性化合物提供了依据。
