Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, China.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012 Aug;29(8):1194-201. doi: 10.1080/19440049.2012.692395.
Desorption corona beam ionisation (DCBI), the relatively novel ambient mass spectrometry (MS) technique, was utilised to screen for illicit additives in weight-loss food. The five usually abused chemicals - fenfluramine, N-di-desmethyl sibutramine, N-mono-desmethyl sibutramine, sibutramine and phenolphthalein - were detected with the proposed DCBI-MS method. Fast single-sample and high-throughput analysis was demonstrated. Semi-quantification was accomplished based on peak areas in the ion chromatograms. Four illicit additives were identified and semi-quantified in commercial samples. As there was no tedious sample pre-treatment compared with conventional HPLC methods, high-throughput analysis was achieved with DCBI. The results proved that DCBI-MS is a powerful tool for the rapid screening of illicit additives in weight-loss dietary supplements.
解吸电晕束离子化（DCBI），一种相对新颖的环境质谱（MS）技术，被用于筛选减肥食品中的非法添加剂。该方法检测到五种常见的滥用化学品——芬氟拉明、N-去二甲苯丁胺、N-单去二甲苯丁胺、西布曲明和酚酞。该方法具有快速、单样本、高通量分析的特点。基于离子色谱图中的峰面积进行半定量分析。在商业样品中鉴定和半定量了四种非法添加剂。与传统的 HPLC 方法相比，该方法无需繁琐的样品预处理，实现了高通量分析。结果表明，DCBI-MS 是快速筛选减肥膳食补充剂中非法添加剂的有力工具。
