Ménézo Yves, Entezami Frida, Lichtblau Isabelle, Belloc Stephanie, Cohen Marc, Dale Brian
UNILABS, Laboratoire Dynabio, Polyclinique du Cotentin, 50120 Equeurdreville, France.
UNILABS, Laboratoire d'Eylau, 55 Rue St Didier, Paris, France.
Zygote. 2014 Feb;22(1):80-90. doi: 10.1017/S0967199412000263. Epub 2012 Jul 12.
One of the most important concerns in assisted reproduction (ART), and in particular ICSI, is the quality of sperm DNA. Oxidative stress is one of the major causes of damage to DNA and attempting to reduce generation of DNA damage related to reactive oxygen species (ROS) through consumption of antioxidants is often tempting. However, current antioxidant treatments, given irrespectively of clinically quantified deficiencies, are poorly efficient, potentially detrimental and over-exposure is risky. Here we discuss new treatments in relation to present day concepts on oxidative stress. This discussion includes stimulation of endogenous anti-ROS defense i.e. glutathione synthesis and recycling of homocysteine, the epicentre of multiple ROS-linked pathologies.
辅助生殖技术（ART）尤其是卵胞浆内单精子注射（ICSI）中最重要的问题之一是精子DNA的质量。氧化应激是DNA损伤的主要原因之一，通过摄入抗氧化剂来减少与活性氧（ROS）相关的DNA损伤的产生往往很诱人。然而，目前的抗氧化剂治疗，无论临床量化的缺陷如何，效率都很低，可能有害，过度暴露有风险。在这里，我们讨论与当今氧化应激概念相关的新治疗方法。这种讨论包括刺激内源性抗ROS防御，即谷胱甘肽合成和同型半胱氨酸的循环利用，同型半胱氨酸是多种与ROS相关疾病的核心。
