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Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.

作者信息

Chen M S, Walker J, Prusoff W H

出版信息

J Biol Chem. 1979 Nov 10;254(21):10747-53.

PMID:227850
Abstract
摘要

相似文献

1
Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.1型单纯疱疹病毒编码的胸苷和胸苷酸激酶（一种多功能酶）的动力学研究
J Biol Chem. 1979 Nov 10;254(21):10747-53.
2
Characterization of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in cells infected with mutant strains of herpes simplex virus.在1型单纯疱疹病毒转化的细胞以及感染单纯疱疹病毒突变株的细胞中，嘧啶脱氧核糖核苷激酶（胸苷激酶）和胸苷酸激酶作为多功能酶的特性研究
J Virol. 1979 Jun;30(3):942-5. doi: 10.1128/JVI.30.3.942-945.1979.
3
Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.胸苷酸激酶活性与单纯疱疹病毒诱导的嘧啶脱氧核糖核苷激酶的关联。
J Biol Chem. 1978 Mar 10;253(5):1325-7.
4
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.在小鼠模型中，低水平的单纯疱疹病毒胸苷 - 胸苷酸激酶对某些抗病毒药物的敏感性或潜伏状态并无限制作用。
Virology. 1989 Feb;168(2):221-31. doi: 10.1016/0042-6822(89)90261-4.
5
Deoxythymidine kinase induced in the HELA TK- cells by herpes simplex virus type I and type II. Substrate specificity and kinetic behavior.单纯疱疹病毒I型和II型在HELA TK-细胞中诱导产生的脱氧胸苷激酶。底物特异性和动力学行为。
Biochim Biophys Acta. 1976 Dec 8;452(2):370-81. doi: 10.1016/0005-2744(76)90186-8.
6
Herpes simplex virus type 2 induced pyrimidine nucleoside kinase: enzymatic basis for the selective antiherpetic effect of 5-halogenated analogues of deoxycytidine.2型单纯疱疹病毒诱导的嘧啶核苷激酶：脱氧胞苷5-卤代类似物选择性抗疱疹作用的酶学基础。
Biochemistry. 1978 Mar 7;17(5):920-8. doi: 10.1021/bi00598a028.
7
Herpesvirus proteins: induction of nucleoside phosphotransferase activity after herpes simplex virus infection.疱疹病毒蛋白：单纯疱疹病毒感染后核苷磷酸转移酶活性的诱导
J Virol. 1976 Mar;17(3):1056-9. doi: 10.1128/JVI.17.3.1056-1059.1976.
8
An optimized thymidylate kinase assay, based on enzymatically synthesized 5-[125I]iododeoxyuridine monophosphate and its application to an immunological study of herpes simplex virus thymidine-thymidylate kinases.一种基于酶促合成的5-[125I]碘脱氧尿苷单磷酸的优化胸苷酸激酶测定法及其在单纯疱疹病毒胸苷-胸苷酸激酶免疫学研究中的应用。
Anal Biochem. 1987 May 1;162(2):500-10. doi: 10.1016/0003-2697(87)90426-x.
9
Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.对N2-苯基鸟嘌呤和L-胸苷进行的动力学研究表明，单纯疱疹病毒1型胸苷激酶和胸苷酸激酶共用一个共同的活性位点。
Biochem J. 1994 Aug 15;302 ( Pt 1)(Pt 1):279-82. doi: 10.1042/bj3020279.
10
Metabolic alterations of liver regeneration. XV. Cadmium-mediated depression of thymidine and thymidylate kinase induction in rats.肝脏再生的代谢变化。十五。镉介导的大鼠胸腺嘧啶核苷和胸苷酸激酶诱导的抑制作用。
Chem Biol Interact. 1979 May;25(2-3):355-62. doi: 10.1016/0009-2797(79)90057-7.

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Defining a Core Genome for the Herpesvirales and Exploring their Evolutionary Relationship with the Caudovirales.定义疱疹病毒目（Herpesvirales）的核心基因组并探索其与长尾病毒目（Caudovirales）的进化关系。
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Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.DNA聚合酶γ的多态性影响酿酒酵母中的线粒体DNA稳定性和核苷类逆转录酶抑制剂诱导的线粒体毒性。
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Regulation and function of adult neurogenesis: from genes to cognition.
成体神经发生的调控与功能：从基因到认知
Physiol Rev. 2014 Oct;94(4):991-1026. doi: 10.1152/physrev.00004.2014.
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Phosphodeoxyribosyltransferases, designed enzymes for deoxyribonucleotides synthesis.磷酸脱氧核糖基转移酶，设计用于合成脱氧核苷酸的酶。
J Biol Chem. 2013 Mar 1;288(9):6534-41. doi: 10.1074/jbc.M112.446492. Epub 2013 Jan 16.
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Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses.4'-硫代次黄嘌呤核苷和胸苷类似物抗正痘病毒的活性。
Viruses. 2010 Sep;2(9):1968-1983. doi: 10.3390/v2091968. Epub 2010 Sep 16.
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Engineering Kinases to Phosphorylate Nucleoside Analogs for Antiviral and Cancer Therapy.通过工程化激酶使核苷类似物磷酸化用于抗病毒和癌症治疗
Chimia (Aarau). 2009 Nov 1;63(11):737-744. doi: 10.2533/chimia.2009.737.
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The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.核苷类似物D-碳环胸苷可阻断HIV-1逆转录。
J Med Chem. 2009 Sep 10;52(17):5356-64. doi: 10.1021/jm801176e.
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Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.北甲氧基碳胸腺嘧啶对卡波西肉瘤相关疱疹病毒具有强大的抗病毒活性。
Antimicrob Agents Chemother. 2005 Dec;49(12):4965-73. doi: 10.1128/AAC.49.12.4965-4973.2005.
9
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.为提高更昔洛韦或阿昔洛韦活性而构建的1型单纯疱疹病毒胸苷激酶突变体的特性分析。
Protein Sci. 2002 Sep;11(9):2267-72. doi: 10.1110/ps.2460102.
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Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.人胸苷激酶可在功能上替代单纯疱疹病毒1型胸苷激酶，用于在小鼠感觉神经节中的病毒复制以及在植入后从潜伏状态重新激活。
J Virol. 1998 Aug;72(8):6710-5. doi: 10.1128/JVI.72.8.6710-6715.1998.