2型单纯疱疹病毒诱导的嘧啶核苷激酶：脱氧胞苷5-卤代类似物选择性抗疱疹作用的酶学基础。 - Suppr

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超能文献

Herpes simplex virus type 2 induced pyrimidine nucleoside kinase: enzymatic basis for the selective antiherpetic effect of 5-halogenated analogues of deoxycytidine.

作者信息

Dobersen M J, Greer S

出版信息

Biochemistry. 1978 Mar 7;17(5):920-8. doi: 10.1021/bi00598a028.

DOI:10.1021/bi00598a028

PMID:204334

Abstract

摘要

相似文献

Herpes simplex virus type 2 induced pyrimidine nucleoside kinase: enzymatic basis for the selective antiherpetic effect of 5-halogenated analogues of deoxycytidine.2型单纯疱疹病毒诱导的嘧啶核苷激酶：脱氧胞苷5-卤代类似物选择性抗疱疹作用的酶学基础。

Biochemistry. 1978 Mar 7;17(5):920-8. doi: 10.1021/bi00598a028.

Nucleoside analogues with clinical potential in antivirus chemotherapy. The effect of several thymidine and 2'-deoxycytidine analogue 5'-triphosphates on purified human (alpha, beta) and herpes simplex virus (types 1, 2) DNA polymerases.具有抗病毒化疗临床潜力的核苷类似物。几种胸苷和2'-脱氧胞苷类似物5'-三磷酸对纯化的人（α，β）和单纯疱疹病毒（1型、2型）DNA聚合酶的作用。

Mol Pharmacol. 1981 Sep;20(2):415-22.

Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.1型单纯疱疹病毒编码的胸苷和胸苷酸激酶（一种多功能酶）的动力学研究

J Biol Chem. 1979 Nov 10;254(21):10747-53.

Induction capacity and influence of dThdMP on thymidine kinase activity of type 1 and 2 strains of herpes simplex virus.脱氧胸苷一磷酸对1型和2型单纯疱疹病毒胸苷激酶活性的诱导能力及影响

Arch Virol. 1978;56(3):243-9. doi: 10.1007/BF01317853.

Herpesvirus proteins: induction of nucleoside phosphotransferase activity after herpes simplex virus infection.疱疹病毒蛋白：单纯疱疹病毒感染后核苷磷酸转移酶活性的诱导

J Virol. 1976 Mar;17(3):1056-9. doi: 10.1128/JVI.17.3.1056-1059.1976.

Cell-free synthesis of herpes simplex virus-coded pyrimidine deoxyribonucleoside kinase enzyme.单纯疱疹病毒编码的嘧啶脱氧核糖核苷激酶的无细胞合成

J Virol. 1977 Sep;23(3):455-60. doi: 10.1128/JVI.23.3.455-460.1977.

Kinetic mechanism and inhibition of human liver thymidine kinase.人肝胸苷激酶的动力学机制及抑制作用

Biochim Biophys Acta. 1981 Aug 13;660(2):238-42. doi: 10.1016/0005-2744(81)90165-0.

Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.脱氧胞苷在不丧失抗疱疹活性的情况下，选择性拮抗脱氧胞苷5-卤代类似物细胞毒性的能力。

Antimicrob Agents Chemother. 1982 Sep;22(3):431-41. doi: 10.1128/AAC.22.3.431.

Kinetics of phosphorylation of 5-aza-2'-deoxyycytidine by deoxycytidine kinase.脱氧胞苷激酶对5-氮杂-2'-脱氧胞苷的磷酸化动力学

Biochem Pharmacol. 1979 Apr 15;28(8):1443-4. doi: 10.1016/0006-2952(79)90454-4.

Deoxythymidine kinase induced in the HELA TK- cells by herpes simplex virus type I and type II. Substrate specificity and kinetic behavior.单纯疱疹病毒I型和II型在HELA TK-细胞中诱导产生的脱氧胸苷激酶。底物特异性和动力学行为。

Biochim Biophys Acta. 1976 Dec 8;452(2):370-81. doi: 10.1016/0005-2744(76)90186-8.

引用本文的文献

Biochemical characterization of equine herpesvirus type 3-induced deoxythymidine kinase purified from lytically infected horse embryo dermal fibroblasts.从经裂解感染的马胚胎皮肤成纤维细胞中纯化的马疱疹病毒3型诱导的脱氧胸苷激酶的生化特性

J Virol. 1980 May;34(2):474-83. doi: 10.1128/JVI.34.2.474-483.1980.

Incorporation of 5-substituted analogs of deoxycytidine into DNA of herpes simplex virus-infected or - transformed cells without deamination to the thymidine analog.将脱氧胞苷的5-取代类似物掺入单纯疱疹病毒感染或转化细胞的DNA中，而不会脱氨基形成胸苷类似物。

Antimicrob Agents Chemother. 1983 Mar;23(3):465-76. doi: 10.1128/AAC.23.3.465.

Antimicrob Agents Chemother. 1982 Sep;22(3):431-41. doi: 10.1128/AAC.22.3.431.

Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA.四氢尿苷特异性地促进脱氧胞苷掺入单纯疱疹病毒DNA中。

J Virol. 1981 Mar;37(3):987-93. doi: 10.1128/JVI.37.3.987-993.1981.

Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type 1- and 2-induced thymidine kinase.胸苷激酶的优化检测方法及其在检测抗1型和2型单纯疱疹病毒诱导的胸苷激酶抗体中的应用。

Infect Immun. 1980 Aug;29(2):425-34. doi: 10.1128/iai.29.2.425-434.1980.

Human serum antibodies to varicella-zoster virus thymidine kinase.人血清中针对水痘带状疱疹病毒胸苷激酶的抗体。

Infect Immun. 1982 Apr;36(1):30-7. doi: 10.1128/iai.36.1.30-37.1982.

Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates.用于检测和定量临床分离株中单纯疱疹病毒胸苷激酶缺陷型和胸苷激酶改变型突变体的噬斑放射自显影测定法。

Antimicrob Agents Chemother. 1985 Aug;28(2):181-7. doi: 10.1128/AAC.28.2.181.

Characterization of thymidine kinase and phosphorylation of deoxyribonucleosides in Chlamydomonas reinhardti.莱茵衣藻中胸苷激酶的特性及脱氧核糖核苷的磷酸化作用

Mol Gen Genet. 1979 Nov;176(3):399-409. doi: 10.1007/BF00333104.

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