Kuniyoshi Hisato, Okumura Izumi, Kuroda Rie, Tsujita Natsumi, Arakawa Kenji, Shoji Jun, Saito Tamio, Osada Hiroyuki
Faculty of Applied Biological Science, Graduate School of Biosphere Science, Hiroshima University, Higashi-hiroshima, Hiroshima, Japan.
Biosci Biotechnol Biochem. 2012;76(7):1397-400. doi: 10.1271/bbb.120076. Epub 2012 Jul 7.
We found while screening a chemical library that indomethacin, an inhibitor of prostaglandin biosynthesis, induced strobilation (metamorphosis from the asexual to sexual stage) in the moon jellyfish, Aurelia aurita. Indomethacin initiated strobilation in a dose-dependent manner, but was not involved in the progression of strobilation. Pharmacological experiments suggested that indomethacin could induce strobilation independently of prostaglandin biosynthesis.
在筛选化学文库时，我们发现消炎痛（一种前列腺素生物合成抑制剂）可诱导海月水母（Aurelia aurita）进行横裂生殖（从无性阶段到有性阶段的变态）。消炎痛以剂量依赖的方式引发横裂生殖，但不参与横裂生殖的进展过程。药理学实验表明，消炎痛可独立于前列腺素生物合成诱导横裂生殖。
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