Chen Jinhong, Geng Xiaoyu, Li Bingbing, Xie Jinyao, Ma Jieying, Qin Zhen, Wang Mingke, Yang Jishun
Naval Medical Center of PLA, Naval Medical University, Shanghai 200052, China.
Curr Issues Mol Biol. 2024 Oct 18;46(10):11630-11645. doi: 10.3390/cimb46100690.
Metamorphosis control is pivotal in preventing the outbreak of jellyfish, and it is often studied using common model organisms. The widespread use of the ultraviolet blocking agent homosalate in cosmetics poses a threat to marine ecosystems. Although the impact of homosalate on marine organisms has been extensively examined, there is a notable absence of research on its effects on jellyfish metamorphosis and the underlying mechanisms, warranting further investigation. In this study, we first established a study model by using 5-methoxy-2-methylindole to induce metamorphosis, and selected homosalate as a PI3K agonist and an ERK agonist, while we used YS-49 as a specific PI3K agonist, as well as ERK knockdown, to observe their effect on the metamorphosis of . The results showed that an metamorphosis model was established successfully, and the PI3K agonist homosalate, YS-49, and the knockdown of ERK molecules could significantly delay the metamorphosis development of . We propose that activating PI3K/Akt and inhibiting the ERK pathway are involved in the delayed development of , which provides a new strategy for the prevention and control of jellyfish blooms.
变态控制对于防止水母爆发至关重要，并且通常使用常见模式生物进行研究。紫外线阻断剂胡莫柳酯在化妆品中的广泛使用对海洋生态系统构成威胁。尽管胡莫柳酯对海洋生物的影响已得到广泛研究，但关于其对水母变态及其潜在机制的影响却明显缺乏研究，值得进一步探讨。在本研究中，我们首先通过使用5-甲氧基-2-甲基吲哚诱导变态建立了一个研究模型，并选择胡莫柳酯作为PI3K激动剂和ERK激动剂，同时我们使用YS-49作为特异性PI3K激动剂以及ERK敲低，以观察它们对[此处原文缺失相关对象]变态的影响。结果表明成功建立了[此处原文缺失相关对象]变态模型，PI3K激动剂胡莫柳酯、YS-49以及ERK分子的敲低均可显著延迟[此处原文缺失相关对象]的变态发育。我们提出激活PI3K/Akt和抑制ERK途径参与了[此处原文缺失相关对象]的延迟发育，这为水母大量繁殖的防控提供了一种新策略。
