Dávila-Gutiérrez G, Mondragón-Pineda A, Alcalá-Negrete H
Servicio de Neurología, Hospital Infantil de México Federico Gómez, D.F.
Bol Med Hosp Infant Mex. 1990 Oct;47(10):694-7.
Below is report on our experience using a relatively new benzodiazepine as treatment for refractory epilepsy in 30 children. All of the patients had a severely fixed encephalopathy; 17 presented mixed epilepsy, 9 had Lennox-Gastaut syndrome and 4 others, West Syndrome. The seizures were totally controlled in 20% of the children; in a proportion superior to 75%, seizures were decreased in 46% of the patients. There were positive results in 6% of the cases and side-effects were seen in 13%. The usefulness of the clobazam as a co-adjuvant medication in the control of refractory epileptic seizures was demonstrated since the number of seizures decreased from 15 to 3 per day.
