Vajda F J, Bladin P F, Parsons B J
Clin Exp Neurol. 1985;21:177-82.
A benzodiazepine drug, clobazam, was evaluated in 14 refractory epileptic patients, nine of whom received the drug double-blind. Ten patients have been given clobazam long enough to assess results. Four showed marked benefit, four failed to respond and two showed a transient benefit which was maintained by dose changes of both clobazam and clonazepam. Side effects were minimal; doses ranged from 15 to 60 mg per day. Clobazam may have place in the treatment of the Lennox Gastaut syndrome and other types of refractory seizures.
对一种苯二氮䓬类药物氯巴占在14例难治性癫痫患者中进行了评估，其中9例患者接受了双盲给药。10例患者服用氯巴占的时间足够长以评估结果。4例显示出明显疗效，4例无反应，2例显示出短暂疗效，通过调整氯巴占和氯硝西泮的剂量得以维持。副作用极小；剂量范围为每日15至60毫克。氯巴占在治疗伦诺克斯-加斯东综合征及其他类型的难治性癫痫发作中可能有一席之地。
