Department of Cardiology, Jichi Medical University, Shimotsuke, Japan.
Circ J. 2012;76(11):2647-52. doi: 10.1253/circj.cj-12-0093. Epub 2012 Jul 7.
S100A12, a calgranulin family protein released from white blood cells, is involved in inflammatory cardiovascular disease. It was hypothesized that the plasma level of S100A12 can be used to predict outcome in patients with chronic coronary artery disease (CAD). The purpose of this study was to clarify the clinical significance of S100A12 in patients with stable CAD.
A total of 652 patients with stable CAD were studied. All patients underwent percutaneous coronary intervention and successful revascularization. Major adverse cardiovascular events (MACE) were defined as a composite of events of CHF, recurrence of angina pectoris, acute myocardial infarction, stroke, critical arrhythmia, intervention to peripheral arteries and cardiac death. The mean follow-up period was 973±639 days. MACE occurred in 108 patients (16.6%). Plasma S100A12 level had a significant positive correlation with high-sensitivity C-reactive protein (hs-CRP) level. On Kaplan-Meier curve analysis the incidence of MACE was significantly different among S100A12 quartiles (P=0.026). The highest S100A12 quartile (Q4) had a significantly higher MACE rate than the lowest quartile (Q1) (P=0.002). In contrast, hs-CRP was not significant for predicting MACE in the present subjects (P=0.074). A Cox proportional hazard model showed that S100A12 was an independent factor for predicting MACE in multivariate models.
S100A12 could be a novel biomarker for predicting cardiovascular events for predicting MACE in patients with stable CAD.
S100A12 是一种白细胞来源的钙粒蛋白家族蛋白，参与炎症性心血管疾病。据推测，S100A12 的血浆水平可用于预测慢性冠状动脉疾病（CAD）患者的结局。本研究旨在阐明 S100A12 在稳定型 CAD 患者中的临床意义。
共纳入 652 例稳定型 CAD 患者。所有患者均接受经皮冠状动脉介入治疗和成功的血运重建。主要不良心血管事件（MACE）定义为 CHF、心绞痛复发、急性心肌梗死、中风、严重心律失常、外周动脉介入和心脏性死亡的复合事件。平均随访时间为 973±639 天。108 例患者（16.6%）发生 MACE。S100A12 水平与高敏 C 反应蛋白（hs-CRP）水平呈显著正相关。Kaplan-Meier 曲线分析显示，S100A12 四分位组之间的 MACE 发生率存在显著差异（P=0.026）。S100A12 四分位最高组（Q4）的 MACE 发生率明显高于最低组（Q1）（P=0.002）。相反，在本研究对象中，hs-CRP 对预测 MACE 无显著意义（P=0.074）。Cox 比例风险模型显示，S100A12 是多变量模型中预测 MACE 的独立因素。
S100A12 可能是预测稳定型 CAD 患者心血管事件的新型生物标志物。
