Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands.
Hum Reprod. 2012 Oct;27(10):2966-70. doi: 10.1093/humrep/des258. Epub 2012 Jul 10.
Dizygotic twin pregnancies after IVF treatment are the result of multiple embryos transferred into the uterine cavity, followed by successful double implantation. Factors that increase the chance of multiple implantation after IVF are relatively unknown. The present study aimed to investigate whether features of body composition, such as maternal height, weight and body mass index (BMI) are associated with an increased chance of dizygotic twinning after IVF with double embryo transfer (DET).
This study was conducted using data from a large Dutch nationwide cohort that comprised 19 861 women who had IVF or ICSI treatment between 1983 and 1995 (OMEGA study). First 'fresh' IVF and ICSI cycles with DET resulting in a delivery of a singleton or twin (living as well as stillborn) were selected. A multivariable logistic regression analysis was performed, with the delivery of a singleton or twin as the dependent variable and height, weight, BMI, maternal age, number of retrieved oocytes, use of alcohol, smoking, highest level of education and parity as independent variables.
Of the 6598 women who completed their first IVF or ICSI cycle, 2375 had DET, resulting in 496 deliveries of 371 singletons and 125 twins. Multivariable regression analysis revealed that tall women (>1.74 cm) and women with a high number of retrieved oocytes (>8) had an increased chance of dizygotic twinning [OR: 1.8 (95% CI: 1.0-3.4) and OR: 2.2 (95% CI: 1.3-3.8), respectively].
Our data demonstrate that tall stature and increased number of retrieved oocytes independently increase the chance of dizygotic twinning after IVF with DET.
体外受精（IVF）治疗后发生的双卵双胞胎妊娠是将多个胚胎移植到子宫腔后成功双着床的结果。增加 IVF 后多胚胎着床机会的因素尚不清楚。本研究旨在探讨身体成分特征（如母亲身高、体重和体重指数（BMI））是否与 IVF 后双胚胎移植（DET）发生双卵双胞胎的机会增加有关。
本研究使用了一个大型荷兰全国队列的数据，该队列包括 1983 年至 1995 年间接受 IVF 或卵胞浆内单精子注射（ICSI）治疗的 19861 名女性（OMEGA 研究）。选择首次进行“新鲜”IVF 和 ICSI 周期，采用 DET 并分娩单胎或双胎（活产和死产）。采用多变量逻辑回归分析，以分娩单胎或双胎为因变量，身高、体重、BMI、母亲年龄、获卵数、是否饮酒、吸烟、最高教育水平和产次为自变量。
在完成首次 IVF 或 ICSI 周期的 6598 名女性中，有 2375 名接受了 DET，导致 496 名分娩 371 名单胎和 125 名双胎。多变量回归分析显示，高个子女性（>1.74 厘米）和获卵数多的女性（>8 个）发生双卵双胞胎的几率增加[比值比（OR）：1.8（95%置信区间：1.0-3.4）和 OR：2.2（95%置信区间：1.3-3.8）]。
我们的数据表明，高身材和获卵数增加可独立增加 IVF 后 DET 发生双卵双胞胎的几率。
