Fuster-Matanzo Almudena, Llorens-Martín María, Jurado-Arjona Jerónimo, Avila Jesús, Hernández Félix
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, (CSIC/UAM) Madrid, Spain.
Front Neurosci. 2012 Jul 9;6:104. doi: 10.3389/fnins.2012.00104. eCollection 2012.
Tau protein is a microtubule-associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions. Tau metabolism has attracted much attention because of its role in neurodegenerative disorders called tauopathies, mainly Alzheimer disease. Here, we review recent findings suggesting that axonal outgrowth in subgranular zone during adult hippocampal neurogenesis requires a dynamic microtubule network and tau protein facilitates to maintain that dynamic cytoskeleton. Those functions are carried out in part by tau isoform with only three microtubule-binding domains (without exon 10) and by presence of hyperphosphorylated tau forms. Thus, tau is a good marker and a valuable tool to study new axons in adult neurogenesis.
tau蛋白是一种在轴突区发现的微管相关蛋白，在正常生理条件下可稳定神经元微管。由于tau蛋白在称为tau蛋白病的神经退行性疾病（主要是阿尔茨海默病）中的作用，其代谢引起了广泛关注。在此，我们综述了最近的研究结果，这些结果表明，成体海马神经发生过程中颗粒下区的轴突生长需要动态微管网络，而tau蛋白有助于维持这种动态细胞骨架。这些功能部分由仅具有三个微管结合结构域（无外显子10）的tau异构体以及高磷酸化tau形式的存在来执行。因此，tau蛋白是研究成体神经发生中新轴突的良好标志物和有价值的工具。
