轮状病毒免疫接种计划启动后5岁以下儿童的急性轮状病毒胃肠炎

Acute rotavirus gastroenteritis in children younger than 5 years of age after initiation of rotavirus immunization schedule.

作者信息

García-Puebla Ana, García-Fragoso Lourdes

机构信息

UPR School of Medicine, Department of Pediatrics, Neonatology Section, San Juan, Puerto Rico.

出版信息

Bol Asoc Med P R. 2012 Jan-Mar;104(1):4-7.

PMID:22788071

Abstract

UNLABELLED

Rotavirus is the most common viral etiology of acute gastroenteritis in children. Oral rotavirus vaccine administration to infants was incorporated in 2007. The objective of this study is to determine the frequency of acute rotavirus gastroenteritis (ARGE) after the initiation of the rotavirus immunization schedule.

METHODOLOGY

The study included children younger than 5 years of age admitted to San Jorge Children's Hospital from 2005-2008 with ARGE.

RESULTS

There were 7,686 cases of acute gastroenteritis during the study period with 15% caused by Rotavirus. The peak season occurred from January through June. Rotavirus accounted for 22% of the acute gastroenteritis cases in the years pre-vaccination (2005-2006) and only 8.5 % in the post-vaccination years (2007-2008) (p < 0.01) with a 68% reduction in ARGE hospitalizations after vaccination.

CONCLUSIONS

Our study supports the significant decline in ARGE after routine administration rotavirus vaccine in Puerto Rico.

摘要

未标注

轮状病毒是儿童急性胃肠炎最常见的病毒病因。2007年开始对婴儿接种口服轮状病毒疫苗。本研究的目的是确定轮状病毒免疫接种计划启动后急性轮状病毒胃肠炎（ARGE）的发病频率。

方法

该研究纳入了2005年至2008年因急性轮状病毒胃肠炎入住圣豪尔赫儿童医院的5岁以下儿童。

结果

研究期间共发生7686例急性胃肠炎病例，其中15%由轮状病毒引起。发病高峰期为1月至6月。在疫苗接种前的年份（2005 - 2006年），轮状病毒占急性胃肠炎病例的22%，而在疫苗接种后的年份（2007 - 2008年）仅占8.5%（p < 0.01），疫苗接种后轮状病毒胃肠炎住院病例减少了68%。