Department of Gastroenterology & Hepatology, Mayo Clinic, Jacksonville, FL, United States.
Dig Liver Dis. 2012 Oct;44(10):844-8. doi: 10.1016/j.dld.2012.06.005. Epub 2012 Jul 11.
The utility of Carcino Embryonic Antigen (CEA) in differentiating malignant from benign pancreatic cysts is controversial. We sought to examine the role of CEA in differentiating benign from malignant cysts and its utility in progression of cyst size in follow-up.
Retrospective chart review of patients who underwent Endoscopic Ultrasound with Fine Needle Aspiration for mucinous cysts between 1998 and 2010. CEA was measured in benign and malignant mucinous cysts. Coefficient of determination (R(2)) was used to measure the association between change in cyst size and CEA. Mann-Whitney test was used to compare the median values of CEA.
143 patients (38.4% males) were included (mean age 68.9 ± 0.8 years). 105 patients had intra-cystic CEA measured. 63 patients underwent surgery while 80 patients were in the follow-up group. In the surgical group, median CEA value for benign and malignant mucinous neoplasms was 796 and 438 ng/ml, respectively (p=0.79). The median follow-up was 21 months. There was no correlation between CEA level and progression in cyst size in patients who had >6 months of follow-up, R(2)=0.0002. Malignant transformation was observed in 5 (5.9%) patients.
CEA level was not predictive of malignant cyst nor cyst size progression over follow-up.
癌胚抗原（CEA）在鉴别胰腺良恶性囊肿方面的作用仍存在争议。本研究旨在探讨 CEA 在鉴别良恶性囊肿中的作用及其在囊肿大小随访进展中的应用。
回顾性分析 1998 年至 2010 年间接受超声内镜引导下细针抽吸术的黏液性囊肿患者的病历。测量良性和恶性黏液性囊肿中的 CEA。决定系数（R²）用于衡量囊肿大小变化与 CEA 之间的关联。采用 Mann-Whitney 检验比较 CEA 的中位数。
共纳入 143 例患者（男性占 38.4%）（平均年龄 68.9±0.8 岁）。105 例患者的囊内 CEA 得到了测量。63 例患者接受了手术，80 例患者进入了随访组。在手术组中，良性和恶性黏液性肿瘤的 CEA 中位数分别为 796 和 438ng/ml（p=0.79）。中位随访时间为 21 个月。在随访时间>6 个月的患者中，CEA 水平与囊肿大小的进展之间无相关性，R²=0.0002。5 例（5.9%）患者发生了恶性转化。
CEA 水平不能预测恶性囊肿或随访期间囊肿大小的进展。
