Department of Gerontology, St James's Hospital, James's St, Dublin D8, Ireland.
Age Ageing. 2012 Nov;41(6):810-3. doi: 10.1093/ageing/afs088. Epub 2012 Jul 11.
we aimed to investigate on the potential relationship between vitamin D and orthostatic hypotension (OH) in a case-control model in older adults.
all participants were community-dwelling adults who were not taking vitamin D supplements. Cases were subjects aged 64 or older who were diagnosed with OH at a Falls and Blackout Unit. Controls were age- (within 5 years) and gender-matched subjects who had no history of blackouts, falls or orthostatic dizziness in the preceding year. OH was defined according to standard criteria and was diagnosed with an active stand test. Serum vitamin D [25(OH)D] was measured by radioimmunoassay.
seventy-six subjects were included in the analysis (38 controls and 38 cases). Twenty-four in each group were female and mean age was between 78 and 79 years. Subjects with OH had lower serum 25(OH)D compared to controls (mean difference = 20.6 nmol/l, P = 0.0002). Lower vitamin D status was associated with an increased risk of OH after adjustment for season, body mass index, presence of stroke, diabetes and angina (P = 0.035) but not with impaired orthostatic haemodynamics.
findings suggest that vitamin D may play a role in the aetiology of OH. Further studies will be required to explore on this relationship.
我们旨在研究维生素 D 与老年人直立性低血压（OH）之间的潜在关系，采用病例对照模型进行研究。
所有参与者均为未服用维生素 D 补充剂的社区居住成年人。病例组为年龄在 64 岁及以上，在跌倒和晕厥单元被诊断为 OH 的患者。对照组为年龄（相差不超过 5 岁）和性别匹配的患者，在过去一年中无晕厥、跌倒或直立性头晕史。根据标准标准，通过主动站立试验诊断 OH。采用放射免疫分析法测量血清维生素 D [25（OH）D]。
76 名受试者纳入分析（38 名对照组和 38 名病例组）。每组中有 24 名女性，平均年龄在 78 至 79 岁之间。与对照组相比，OH 患者的血清 25（OH）D 水平较低（平均差异= 20.6 nmol/L，P = 0.0002）。调整季节、体重指数、中风、糖尿病和心绞痛后，维生素 D 状态较低与 OH 风险增加相关（P = 0.035），但与直立性血液动力学障碍无关。
研究结果表明，维生素 D 可能在 OH 的发病机制中发挥作用。需要进一步研究来探索这种关系。
