儿童肥胖与脉压之间的关系：1988 - 1994年美国国家健康和营养检查调查（NHANES）结果
Relationship between obesity and pulse pressure in children: results of the National Health and Nutrition Survey (NHANES) 1988-1994.
作者信息
Chandramohan Gangadarshni, Kalantar-Zadeh Kamyar, Kermah Dulcie, Go Sheena Cecille Marie, Vaziri Nosratola D, Norris Keith C
机构信息
Division of Pediatric Nephrology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
出版信息
J Am Soc Hypertens. 2012 Jul-Aug;6(4):277-83. doi: 10.1016/j.jash.2012.05.002.
BACKGROUND
Obesity is a known cardiometabolic risk factor in children. In adults, pulse pressure (PP) is a known predictor and a risk factor of cardiovascular (CV) diseases. In this study, we examined the association between measures of obesity and PP in children.
METHODS
A retrospective analysis of 4667 children ages 6-17 years from the National Health and Nutrition Survey (1988-1994) was performed. We defined wide PP as 4th quartile PP and high waist circumference (WC) as >75th percentile based on age and gender.
RESULTS
There were 51% boys, 74% whites, 16% blacks, 10% Hispanics, 12% obese, 26% with high WC, 26% with wide PP, and 9% with high blood pressure (BP). Prevalence of wide PP was high among obese children. A significantly higher mean PP was observed in boys, Blacks, obese, those with high WC and high BP. The adjusted odds ratio (OR) for wide PP was higher in boys, Blacks, and those with high WC.
CONCLUSION
There was a statistically significant independent association observed between wide PP and high WC, but not with obesity based on BMI. Further exploration of wide PP as a CV risk factor in childhood and its relationship to CV outcomes appears warranted.
背景
肥胖是儿童已知的心血管代谢危险因素。在成年人中，脉压（PP）是已知的心血管（CV）疾病预测指标和危险因素。在本研究中，我们探讨了儿童肥胖指标与PP之间的关联。
方法
对来自国家健康与营养调查（1988 - 1994年）的4667名6至17岁儿童进行回顾性分析。我们将宽脉压定义为PP的第4四分位数，将高腰围（WC）定义为基于年龄和性别的>第75百分位数。
结果
男孩占51%，白人占74%，黑人占16%，西班牙裔占10%，肥胖者占12%，高腰围者占26%，宽脉压者占26%，高血压（BP）者占9%。宽脉压在肥胖儿童中的患病率较高。在男孩、黑人、肥胖者、高腰围者和高血压者中观察到显著更高的平均脉压。男孩、黑人以及高腰围者宽脉压的调整优势比（OR）更高。
结论
宽脉压与高腰围之间存在统计学上显著的独立关联，但与基于BMI的肥胖无关。进一步探索宽脉压作为儿童心血管危险因素及其与心血管结局的关系似乎是有必要的。
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