Hirschler Valeria, Molinari Claudia, Maccallini Gustavo, Hidalgo Mariana, Gonzalez Claudio
1 Department of Pharmacology, University of Buenos Aires , Buenos Aires, Argentina .
2 Hidalgo Laboratories , Buenos Aires, Argentina .
Child Obes. 2016 Feb;12(1):77-85. doi: 10.1089/chi.2015.0058. Epub 2015 Dec 24.
Central obesity is associated with increased risk of type 2 diabetes.
The study objectives were to develop waist circumference (WC) percentiles, to determine if WC is associated with metabolic risk, and to compare our WC percentiles with those reported in the 2007-2010 National Health and Nutrition Examination Survey (NHANES).
A cross-sectional study of 1232 children (606 boys ) 5-14 years was performed from 2011 to 2014 in indigenous Koya children from northwestern Argentina. Anthropometric characteristics, glucose, lipids, and insulin levels were measured. Sex-specific reference percentiles were computed using the Lambda-Mu-Sigma (LMS) method. We obtained 2007-2010 NHANES data for comparison with our results.
Compared with the NHANES 90th percentile, WC values for children in this study were lower by an average of 11.05 cm for girls and 12.66 cm for boys. The prevalence of low high-density lipoprotein cholesterol (HDL-C) was 11.8% in children with WC ≤50th percentile, 10.3% in children with WC >50th-70th percentile, 17.5% in children with WC >70th-90th percentile, and 21.3% in children with WC >90th percentile. The prevalence of high triglycerides (TG) was 19.5% in children with WC ≤50th percentile, 19.9% in children with WC >50th-70th percentile, 28.8% in children with WC >70th-90th percentile, and 39.7% in children with WC >90th percentile. Multiple logistic regression analyses showed that high TG values (>150 mg/dL) were significantly associated with WC [odds ratio (OR)] 1.05; 95% confidence interval (CI) 1.03-1.08; and low HDL-C values (<35 mg/dL) were significantly associated with WC (OR 1.04; 95% CI 1.01-1.06), adjusted for age and gender.
We present for the first time WC reference data for indigenous Koya children ages 5-14 years. There was a significant association between WC and dyslipidemia in this community. Compared with the NHANES WC percentiles, our WC values were lower. These differences possibly reflect ethnicity or the lower prevalence of obesity.
中心性肥胖与2型糖尿病风险增加相关。
本研究的目的是制定腰围（WC）百分位数，确定WC是否与代谢风险相关，并将我们的WC百分位数与2007 - 2010年国家健康和营养检查调查（NHANES）报告的结果进行比较。
2011年至2014年对阿根廷西北部的科亚族土著1232名5 - 14岁儿童（606名男孩）进行了横断面研究。测量了人体测量学特征、血糖、血脂和胰岛素水平。使用Lambda - Mu - Sigma（LMS）方法计算了按性别划分的参考百分位数。我们获取了2007 - 2010年NHANES数据以与我们的结果进行比较。
与NHANES第90百分位数相比，本研究中女孩的WC值平均低11.05厘米，男孩低12.66厘米。WC≤第50百分位数的儿童中低高密度脂蛋白胆固醇（HDL - C）的患病率为11.8%，WC＞第50 - 70百分位数的儿童中为10.3%，WC＞第70 - 90百分位数的儿童中为17.5%，WC＞第90百分位数的儿童中为21.3%。高甘油三酯（TG）的患病率在WC≤第50百分位数的儿童中为19.5%，WC＞第50 - 70百分位数的儿童中为19.9%，WC＞第70 - 90百分位数的儿童中为28.8%，WC＞第90百分位数的儿童中为39.7%。多因素logistic回归分析显示，高TG值（＞150mg/dL）与WC显著相关[比值比（OR）]1.05；95%置信区间（CI）1.03 - 1.08；低HDL - C值（＜35mg/dL）与WC显著相关（OR 1.04；95% CI 1.01 - 1.06），经年龄和性别校正。
我们首次给出了5 - 14岁科亚族土著儿童的WC参考数据。该社区中WC与血脂异常之间存在显著关联。与NHANES的WC百分位数相比，我们的WC值较低。这些差异可能反映了种族或肥胖患病率较低。
