Vision Science Research Program, Toronto Western Hospital, Toronto, Ontario, Canada.
Invest Ophthalmol Vis Sci. 2012 Aug 9;53(9):5386-94. doi: 10.1167/iovs.12-9941.
We investigated whether the sensory impairments of amblyopia are associated with a decrease in eye position stability (PS).
The positions of both eyes were recorded simultaneously in three viewing conditions: binocular, monocular fellow eye viewing (right eye for controls), and monocular amblyopic eye viewing (left eye for controls). For monocular conditions, movements of the covered eye were also recorded (open-loop testing). Bivariate contour ellipses (BCEAs), representing the region over which eye positions were found 68.2% of the time, were calculated and normalized by log transformation.
For controls, there were no differences between eyes. Binocular PS (log(10)BCEA = -0.88) was better than monocular PS (log(10)BCEA = -0.59) indicating binocular summation, and the PS of the viewing eye was better than that of the covered eye (log(10)BCEA = -0.33). For patients, the amblyopic eye exhibited a significant decrease in PS during amblyopic eye (log(10)BCEA = -0.20), fellow eye (log(10)BCEA = 0.0004), and binocular (log(10)BCEA = -0.44) viewing. The PS of the fellow eye depended on viewing condition: it was comparable to controls during binocular (log(10)BCEA = -0.77) and fellow eye viewing (log(10)BCEA = -0.52), but it decreased during amblyopic eye viewing (log(10)BCEA = 0.08). Patients exhibited binocular summation during fellow eye viewing, but not during amblyopic eye viewing. Decrease in PS in patients was mainly due to slow eye drifts.
Deficits in spatiotemporal vision in amblyopia are associated with poor PS. PS of amblyopic and fellow eyes is differentially affected depending on viewing condition.
我们研究弱视的感觉障碍是否与眼位稳定性（PS）降低有关。
在三种观察条件下同时记录双眼位置：双眼、单眼对侧眼（对照组右眼）和单眼弱视眼（对照组左眼）。对于单眼条件，还记录了遮盖眼的运动（开环测试）。计算并通过对数转换对双变量轮廓椭圆（BCEA）进行归一化，BCEA 代表眼位 68.2%时间内所在的区域。
对于对照组，双眼之间没有差异。双眼 PS（log(10)BCEA = -0.88）优于单眼 PS（log(10)BCEA = -0.59），表明双眼叠加，注视眼的 PS 优于遮盖眼（log(10)BCEA = -0.33）。对于患者，弱视眼在弱视眼（log(10)BCEA = -0.20）、对侧眼（log(10)BCEA = 0.0004）和双眼（log(10)BCEA = -0.44）观察时，PS 显著降低。对侧眼的 PS 取决于观察条件：在双眼（log(10)BCEA = -0.77）和对侧眼（log(10)BCEA = -0.52）观察时与对照组相当，但在弱视眼观察时降低（log(10)BCEA = 0.08）。患者在对侧眼观察时表现出双眼叠加，但在弱视眼观察时则没有。患者 PS 降低主要是由于缓慢的眼球漂移。
弱视的时空视觉缺陷与 PS 降低有关。弱视眼和对侧眼的 PS 受观察条件的影响而不同。
