Yagi Kiyohito
Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
Gan To Kagaku Ryoho. 2012 Jul;39(7):1099-102.
The hot-water extracts of Lentinula edodes mycelia(LEM)contain carbohydrates, proteins, phenolic compounds, and lignin digest, which perform various physiological activities. LEM has hepatoprotective activities in animals with acute liver injury induced by concanavalin A or D-galactosamine.Moreover, LEM suppresses liver fibrosis and inflammation in mice with chronic liver injury induced by carbon tetrachloride. Vanillic acid and syringic acid contained in LEM also showed hepatoprotective activities in mice with acute and chronic liver injury, and low-molecular-weight lignin maintained the viability of primary cultured hepatocytes treated with carbon tetrachloride. LEM containing anti-oxidation and anti-inflammation activities might be used for alleviating side effects of chemotherapy and preventing the progression of liver cancer for patients with chronic hepatitis.
香菇菌丝体热水提取物（LEM）含有碳水化合物、蛋白质、酚类化合物和木质素消化物，这些物质具有多种生理活性。LEM对伴刀豆球蛋白A或D-半乳糖胺诱导的急性肝损伤动物具有肝保护活性。此外，LEM可抑制四氯化碳诱导的慢性肝损伤小鼠的肝纤维化和炎症。LEM中含有的香草酸和丁香酸在急性和慢性肝损伤小鼠中也表现出肝保护活性，低分子量木质素维持了用四氯化碳处理的原代培养肝细胞的活力。具有抗氧化和抗炎活性的LEM可能用于减轻化疗的副作用，并预防慢性肝炎患者肝癌的进展。
