镍(0)/NaHMDS 加合物通过均裂芳香取代机理介导的未活化芳环的分子内烷基化反应。
Nickel(0)/NaHMDS adduct-mediated intramolecular alkylation of unactivated arenes via a homolytic aromatic substitution mechanism.
机构信息
FRQNT Centre in Green Chemistry and Catalysis, Department of Chemistry, Université de Montréal, PO Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7.
出版信息
Chem Commun (Camb). 2012 Aug 25;48(66):8249-51. doi: 10.1039/c2cc33547f. Epub 2012 Jul 12.
PMID:22790096
Abstract
A variety of polycycles can be synthesized via an intramolecular alkylation cyclization promoted by Ni(PPh(3))(4) and NaHMDS. Mechanistic investigations support the catalytic nature of Ni(0) in the course of TEMPO scavenging experiments and its association with the substrate and NaHMDS to form an adduct by DOSY NMR.
摘要
多种多环化合物可以通过 Ni(PPh(3))(4) 和 NaHMDS 促进的分子内烷基化环化反应合成。机理研究支持了 Ni(0) 在 TEMPO 清除实验过程中的催化性质，以及它与底物和 NaHMDS 通过 DOSY NMR 形成加合物的关联。
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