Shimbayashi Takuya, Okamoto Kazuhiro, Ohe Kouichi
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
Chem Asian J. 2018 Feb 16;13(4):395-399. doi: 10.1002/asia.201701634. Epub 2018 Jan 18.
Intermolecular C-H alkylation of simple arenes in the presence of an iron catalyst has been achieved in a cascade manner with an aminative cyclization triggered by N-O bond cleavage of an alkene-tethered oxime ester. Various arenes, including electron-rich and electron-poor arenes, and heteroarenes can be employed in the reaction system. Regioselectivity and radical trapping experiments support the involvement of alkyl radical species, which undergo a homolytic aromatic substitution (HAS) to afford the arylation products.
在铁催化剂存在下，简单芳烃的分子间C-H烷基化反应已通过级联方式实现，该反应由烯烃连接的肟酯的N-O键裂解引发的胺化环化反应所触发。反应体系中可使用各种芳烃，包括富电子芳烃、缺电子芳烃和杂芳烃。区域选择性和自由基捕获实验支持烷基自由基物种的参与，这些烷基自由基物种通过均裂芳香取代（HAS）反应生成芳基化产物。
