Dhara Rupali, Dhar Pubali, Ghosh Mahua
Dept. of Chemical Technology, University of Calcutta, Kolkata, India.
J Oleo Sci. 2012;61(7):369-75. doi: 10.5650/jos.61.369.
Diacylglycerol (DAG) oil is becoming quite well known for its beneficial effects on obesity and weight related disorders as they are digested and metabolized in a different way, which significantly reduces body weight. The present study was conducted to evaluate the nutritional effect of rice bran oil (RBO) and DAG-rich rice bran oil on rat model. DAG-rich RBO (46.10% DAG) was prepared in the laboratory by enzymatic (TLIM) glycerolysis process. For the feeding experiment, rats (average body weight 130 g) were divided into two groups, each consisting of eight rats. Group RBO was taken as control while DAG-rich RBO (Group DGR) was taken as experimental. Food efficiency ratio, lipid profile of plasma, liver, mesentery and erythrocyte membrane (EM) lipid profile, plasma leptin content, HMG-CoA reductase activity were measured using standard procedures. The results indicated that DAG-rich rice bran oil significantly decreased body weight of rats and content of total cholesterol and triglyceride in plasma compared to the control RBO. The long term use of DAG-rich rice bran oil might be useful for prevention of obesity and incidence of hypercholesterolemia.
二酰甘油（DAG）油因其对肥胖及与体重相关疾病的有益作用而日益闻名，因为它们的消化和代谢方式不同，这能显著减轻体重。本研究旨在评估米糠油（RBO）和富含二酰甘油的米糠油对大鼠模型的营养作用。富含二酰甘油的米糠油（二酰甘油含量为46.10%）是在实验室通过酶促（TLIM）甘油解过程制备的。在喂养实验中，将大鼠（平均体重130克）分为两组，每组八只。以米糠油组作为对照组，富含二酰甘油的米糠油组（DGR组）作为实验组。采用标准程序测量食物效率比、血浆、肝脏、肠系膜和红细胞膜（EM）的脂质谱、血浆瘦素含量、HMG-CoA还原酶活性。结果表明，与对照米糠油相比，富含二酰甘油的米糠油显著降低了大鼠体重以及血浆中总胆固醇和甘油三酯的含量。长期使用富含二酰甘油的米糠油可能有助于预防肥胖和高胆固醇血症的发生。
