Dept. of Chemical Technology, University of Calcutta, Kolkata, India.
Dept. of Home Science, University of Calcutta, Kolkata, India.
J Food Sci Technol. 2013 Aug;50(4):678-86. doi: 10.1007/s13197-011-0388-y. Epub 2011 May 11.
Several recent studies have established that diacylglycerol (DAG) rich oils significantly reduce the body weight. The present study was conducted to evaluate the dietary effects of DAG- rich mustard oil on normal and hypercholesterolemic rats. DAG- rich mustard oil (45.5% DAG) was prepared in the laboratory by enzymatic glycerolysis process. For the feeding experiment, 32 rats were taken and divided into four groups (average body weight 130 g) and body weight gain, food efficiency ratio, lipid profile of plasma, liver, mesentery and erythrocytes membrane (EM), HMG Co-A reductase activity and plasma leptin content were measured and compared with the normal TAG-rich diet. The dietary DAG rich mustard oil significantly decreased body weight and FER compared to TAG rich mustard oil both in normal and hypercholesterolemic rats. The total cholesterol content was decreased with significant increase in HDL- cholesterol by feeding DAG rich diet. Total lipid and TAG content of both liver and mesentery were significantly decreased in DAG diet group compared to control group. Liver HMG CoA: mevalonate ratio was also found to be significantly decreased in the DAG group. Blood leptin level significantly reduced with DAG rich diet compared to the TAG rich dietary groups.
几项最近的研究已经证实，富含二酰基甘油（DAG）的油显著降低体重。本研究旨在评估富含 DAG 的芥菜籽油对正常和高胆固醇血症大鼠的饮食作用。通过酶促甘油解过程在实验室中制备富含 DAG 的芥菜籽油（45.5％DAG）。进行喂养实验时，选取 32 只大鼠并将其分为四组（平均体重 130g），并测量体重增加、食物效率比、血浆、肝脏、肠系膜和红细胞膜（EM）的脂质谱、HMG Co-A 还原酶活性和血浆瘦素含量，并与正常 TAG 丰富饮食进行比较。与富含 TAG 的芥菜籽油相比，富含 DAG 的芥菜籽油可显著降低正常和高胆固醇血症大鼠的体重和 FER。通过喂食富含 DAG 的饮食，总胆固醇含量降低，HDL-胆固醇含量显著增加。与对照组相比，富含 DAG 的饮食组的肝脏和肠系膜中的总脂质和 TAG 含量明显降低。DAG 组的肝 HMG CoA：甲羟戊酸比也发现明显降低。与富含 TAG 的饮食组相比，富含 DAG 的饮食组的血液瘦素水平显著降低。
