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患急性前葡萄膜炎和未患急性前葡萄膜炎的脊柱关节炎患者的人口统计学、临床、实验室及治疗特征。

Demographic, clinical, laboratory and treatment characteristics of spondyloarthritis patients with and without acute anterior uveitis.

作者信息

Gehlen Marcelo, Regis Kelly Cristina, Skare Thelma Larocca

机构信息

Rheumato-ophthalmology Service, Hospital Universitário Evangélico de Curitiba, Curitiba, Paraná, Brazil.

出版信息

Sao Paulo Med J. 2012;130(3):141-4. doi: 10.1590/s1516-31802012000300002.

Abstract

CONTEXT AND OBJECTIVE

Acute anterior uveitis is a common extra-articular manifestation in spondyloarthritis patients. The aim of this study was to compare demographic, clinical, laboratory and treatment data among spondyloarthritis patients with and without acute anterior uveitis.

DESIGN AND SETTING

This was a cross-sectional analytical study at the Rheumatology Outpatient Clinic of the Evangelical University Hospital, Curitiba, Brazil.

METHODS

Spondyloarthritis patients with without acute anterior uveitis were compared regarding demographic data, spondyloarthritis subtype, peripheral arthritis, enthesitis, disease activity, functional index, physical examination, radiological involvement, HLA-B27 and treatment.

RESULTS

Presence of acute anterior uveitis was not found to have any relationship with functional index, degree of radiological involvement, peripheral arthritis or enthesitis. Acute anterior uveitis showed a negative association with skin manifestations (P = 0.04) and a trend towards higher disease activity (P = 0.06).

CONCLUSION

In the study sample, it could not be shown that AAU had any association with the functional and radiological prognoses. The patients with spondyloarthritis with and without acute anterior uveitis did not differ clinically except for a higher proportion of ankylosing spondylitis and smaller presence of skin involvement in those with uveitis.

摘要

背景与目的

急性前葡萄膜炎是脊柱关节炎患者常见的关节外表现。本研究旨在比较有和无急性前葡萄膜炎的脊柱关节炎患者的人口统计学、临床、实验室及治疗数据。

设计与背景

这是一项在巴西库里蒂巴福音大学医院风湿病门诊进行的横断面分析研究。

方法

比较有和无急性前葡萄膜炎的脊柱关节炎患者的人口统计学数据、脊柱关节炎亚型、外周关节炎、附着点炎、疾病活动度、功能指数、体格检查、影像学受累情况、HLA-B27及治疗情况。

结果

未发现急性前葡萄膜炎的存在与功能指数、影像学受累程度、外周关节炎或附着点炎有任何关联。急性前葡萄膜炎与皮肤表现呈负相关(P = 0.04),且有疾病活动度较高的趋势(P = 0.06)。

结论

在本研究样本中,未能表明急性前葡萄膜炎与功能及影像学预后有任何关联。有和无急性前葡萄膜炎的脊柱关节炎患者在临床上并无差异,只是强直性脊柱炎比例较高,且葡萄膜炎患者皮肤受累情况较少。

相似文献

3
[Uveitis and spondyloarthritis: prevalence and relationship with joint disease].
Arq Bras Oftalmol. 2007 Sep-Oct;70(5):827-30. doi: 10.1590/s0004-27492007000500018.

本文引用的文献

1
Use of methotrexate in patients with uveitis.甲氨蝶呤在葡萄膜炎患者中的应用。
Clin Exp Rheumatol. 2010 Sep-Oct;28(5 Suppl 61):S145-50. Epub 2010 Oct 28.
6
Seronegative spondyloarthropathies and the eye.血清阴性脊柱关节病与眼睛
Curr Opin Ophthalmol. 2007 Nov;18(6):476-80. doi: 10.1097/ICU.0b013e3282f0fda2.

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