Soares Michael J, Chakraborty Damayanti, Renaud Stephen J, Kubota Kaiyu, Bu Pengli, Konno Toshihiro, Rumi M A Karim
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA.
J Reprod Dev. 2012;58(3):283-7. doi: 10.1262/jrd.2011-039.
Hemochorial placentation is characterized by trophoblast-directed uterine spiral artery remodeling. The rat and human both possess hemochorial placentation and exhibit remarkable similarities regarding the depth of trophoblast invasion and the extent of uterine vascular modification. In vitro and in vivo research methodologies have been established using the rat as an animal model to investigate the extravillous/invasive trophoblast lineage. With these research approaches, two signaling pathways controlling the differentiation and invasion of the trophoblast cell lineage have been identified: i) hypoxia/hypoxia inducible factor and ii) phosphatidylinositol 3-kinase/AKT/Fos like antigen 1. Dissection of these pathways has facilitated identification of fundamental regulators of the invasive trophoblast cell lineage.
血绒毛膜胎盘形成的特征是滋养层引导的子宫螺旋动脉重塑。大鼠和人类都具有血绒毛膜胎盘形成，并且在滋养层侵入深度和子宫血管改变程度方面表现出显著相似性。已经建立了以大鼠作为动物模型的体外和体内研究方法，以研究绒毛外/侵入性滋养层谱系。通过这些研究方法，已经确定了控制滋养层细胞谱系分化和侵入的两条信号通路：i）缺氧/缺氧诱导因子和ii）磷脂酰肌醇3激酶/蛋白激酶B/类Fos抗原1。对这些通路的剖析有助于识别侵入性滋养层细胞谱系的基本调节因子。
