Sez. Odontostomatologia, University of Parma, Parma, Italy.
Eur Cell Mater. 2012 Jul 12;24:46-59. doi: 10.22203/ecm.v024a04.
Endosseous implants are important tools to replace missing teeth or damaged tissue segments. Their clinical success depends on their integration in bone and, thus, on the response of bone cells to material and surface characteristics. Recent evidence has shown that surface topography and chemistry affect WNT signalling, a pivotal pathway for the commitment of mesenchymal progenitors to the osteoblast lineage and for bone homeostasis. WNT signalling comprises several cascades that, acting through different effectors, modulate several aspects of cell behaviour. It has been shown that cells growing on rough titanium surfaces display a different expression profile for WNT factors, and that surface features can alter the response of bone cells to WNT factors. Although the underlying mechanisms to this regulation are still poorly understood, the present review reports intriguing evidence that that cell cytoskeletal signalling is involved in activating WNT signalling in cells growing on rough implant surfaces.
骨内种植体是替代缺失牙齿或受损组织段的重要工具。它们的临床成功取决于它们在骨骼中的整合，因此取决于骨细胞对材料和表面特性的反应。最近的证据表明，表面形貌和化学性质会影响 WNT 信号通路，该通路是间充质祖细胞向成骨细胞谱系分化和维持骨稳态的关键途径。WNT 信号通路包含几个级联反应，通过不同的效应物作用，调节细胞行为的几个方面。已经表明，在粗糙的钛表面上生长的细胞对 WNT 因子表现出不同的表达谱，并且表面特征可以改变骨细胞对 WNT 因子的反应。尽管这种调节的潜在机制仍知之甚少，但本综述报告了一些有趣的证据，表明细胞细胞骨架信号在粗糙种植体表面上生长的细胞中激活 WNT 信号通路。
