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用于口服结肠给药的pH响应性微球包裹脂质体

Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery.

作者信息

Barea M J, Jenkins M J, Lee Y S, Johnson P, Bridson R H

机构信息

Centre for Formulation Engineering, School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT, UK.

出版信息

Int J Biomater. 2012;2012:458712. doi: 10.1155/2012/458712. Epub 2012 Jun 27.

DOI:10.1155/2012/458712
PMID:22792110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3391899/
Abstract

A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres. The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to improve site-specific release characteristics. In vitro drug release studies showed that LIMs prevented drug release within simulated stomach and small intestine conditions with subsequent drug release occurring in large intestine conditions. The formulation therefore has potential for oral colonic drug delivery.

摘要

一种新型的微球包载脂质体（LIM）制剂已被制备出来，它由负载药物的脂质体包裹在pH响应型Eudragit S100微球中组成。脂质体包含模型药物5-氨基水杨酸（5-ASA），并被壳聚糖包衣，以便在包封于微球内的过程中保护它们，并改善其位点特异性释放特性。体外药物释放研究表明，LIM在模拟胃和小肠条件下可防止药物释放，随后在大肠条件下发生药物释放。因此，该制剂具有口服结肠给药的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/fee33d546ddc/IJBM2012-458712.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/d135a02d0ab8/IJBM2012-458712.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/4d9f9da9c385/IJBM2012-458712.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/5c10ea006a75/IJBM2012-458712.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/2cdd4764bf34/IJBM2012-458712.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/081a6b9128bc/IJBM2012-458712.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/24bf1906d2fb/IJBM2012-458712.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/fee33d546ddc/IJBM2012-458712.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/d135a02d0ab8/IJBM2012-458712.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/4d9f9da9c385/IJBM2012-458712.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/5c10ea006a75/IJBM2012-458712.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/2cdd4764bf34/IJBM2012-458712.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/081a6b9128bc/IJBM2012-458712.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/24bf1906d2fb/IJBM2012-458712.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/3391899/fee33d546ddc/IJBM2012-458712.007.jpg

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本文引用的文献

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