Voskuhl Jens, Ravoo Bart Jan
Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
Chem Soc Rev. 2009 Feb;38(2):495-505. doi: 10.1039/b803782p. Epub 2008 Dec 22.
Vesicles have been a versatile topic of research in chemistry ever since the discovery that, besides phospholipids, synthetic amphiphiles can also form molecular bilayers enclosing a small aqueous compartment. Non-covalent interactions of receptors and ligands or hosts and guests at vesicle surfaces resemble recognition processes at biological membranes, including cell recognition, adhesion and fusion. Molecular recognition at membranes is often mediated by a multivalent instead of a monovalent interaction. This tutorial review describes the basics as well as the latest developments in biomimetic supramolecular chemistry of bilayer vesicles. We describe how molecular recognition can mediate the interaction between vesicles, and how the biomimetic supramolecular chemistry of vesicles furthers our understanding of biological membranes.
自从发现除了磷脂之外，合成两亲分子也能形成包裹小水相区室的分子双层膜以来，囊泡一直是化学领域一个多用途的研究课题。受体与配体或主体与客体在囊泡表面的非共价相互作用类似于生物膜上的识别过程，包括细胞识别、黏附与融合。膜上的分子识别通常由多价而非单价相互作用介导。本教程综述描述了双层囊泡的仿生超分子化学的基础以及最新进展。我们阐述了分子识别如何介导囊泡之间的相互作用，以及囊泡的仿生超分子化学如何增进我们对生物膜的理解。
